{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:57:44Z","timestamp":1790636264404,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Reduced maximal muscle strength and strength endurance have been found in patients with hypermobile Ehlers\u2010Danlos syndrome\/hypermobility spectrum disorder (hEDS\/HSD) and are recognized as common associated features of the disorder. However, the extent to which these parameters change over time is currently not documented. Therefore, the purpose of this 8\u2010year follow\u2010up study was to investigate this evolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty female patients (mean age 41 years) with hEDS\/HSD and 17 controls participated at baseline and 8 years later. Maximal muscle strength and strength endurance tests of the knee flexors and extensors, and 2 lower\u2010extremity posture maintenance tests were performed to evaluate static strength endurance. In addition, muscle mass and density were evaluated by dual\u2010energy x\u2010ray absorptiometry and peripheral quantitative computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maximal muscle strength and strength endurance were significantly lower at both baseline and follow\u2010up in the hEDS\/HSD group compared to the control group (<jats:italic>P<\/jats:italic> \u2264 0.007). Maximal muscle strength of the knee flexors (decreased in the control group: p\u0273<jats:sup>2<\/jats:sup> = 0.139), strength endurance of the knee extensors (decreased in the hEDS\/HSD group and increased in the control group: p\u0273<jats:sup>2<\/jats:sup> = 0.244), and muscle density (decreased in the hEDS\/HSD group: p\u0273<jats:sup>2<\/jats:sup> = 0.263) showed a significantly different evolution over 8 years. No other significant differences in evolution were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased muscle strength was identified at both time points in patients with hEDS\/HSD. The evolution of most muscle strength parameters over time did not significantly differ between groups. Future studies should focus on the effectiveness of different types of muscle training strategies in hEDS\/HSD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24220","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T07:03:42Z","timestamp":1586934222000},"page":"1041-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Does Muscle Strength Change Over Time in Patients With Hypermobile Ehlers\u2010Danlos Syndrome\/Hypermobility Spectrum Disorder? An Eight\u2010Year Follow\u2010Up Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-0968","authenticated-orcid":false,"given":"Marie","family":"Coussens","sequence":"first","affiliation":[{"name":"Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Calders","sequence":"additional","affiliation":[{"name":"Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lapauw","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Celie","sequence":"additional","affiliation":[{"name":"Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiberiu","family":"Banica","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"De Wandele","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Pacey","sequence":"additional","affiliation":[{"name":"Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska","family":"Malfait","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies","family":"Rombaut","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21726"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21643"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638280903514739"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21592"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33231"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36315"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31538"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.4.885"},{"key":"e_1_2_7_12_1","unstructured":"Biodex Medical Systems.Isokinetic testing and data interpretation: data analysis. 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