{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:55:06Z","timestamp":1792270506994,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether patient global assessment of disease activity (PtGA) over the first year of disease course, as part of a Boolean\u2010based definition of remission and considered individually, had a significant relationship with structural progression over 3 years in patients with early arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, observational study using ESPOIR (\u00c9tude et Suivi des Polyarthrites Indiff\u00e9renci\u00e9es R\u00e9centes) cohort data. Remission states were defined as 1) 4\u2010variable remission, which included a tender joint count in 28 joints, a swollen joint count in 28 joints (SJC28), a C\u2010reactive protein (CRP; mg\/dl) level, and PtGA (scored 0\u201310, all scores of \u22641); 2) PtGA near remission, which included the same parameters as 4\u2010variable remission with only PtGA &gt;1 (of a maximum possible score of 10); 3) 3\u2010variable remission (sum of the proportion of patients in 4\u2010variable remission and the proportion of patients in PtGA near remission); or 4) nonremission. The strictest status satisfied both at 6 and 12 months was considered. Radiographic progression was determined as a change of \u22655 points in the total Sharp\/van der Heijde score (\u0394SHS) from baseline to 3 years. The predictive capacities for radiographic damage of different remission definitions were assessed by odds ratio (OR). The association between each individual component of remission with \u0394SHS was tested through multivariate linear regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 520 patients, 7% achieved 4\u2010variable remission and 12% achieved PtGA near remission. Radiographic progression was observed in 29% of patients who achieved 4\u2010variable remission (OR versus nonremission; OR 0.32 [95% confidence interval (95% CI) 0.15, 0.68]) and in 45% of patients with PtGA near remission (OR 0.65 [95% CI 0.38, 1.11]); the comparison was not statistically different (OR 0.49 [95% CI 0.20, 1.18]). In 3\u2010variable remission, radiographic progression was observed in 39%. Of the individual components, only the SJC28 and CRP level were associated with radiographic progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All definitions of remission led to low structural degradation in early arthritis, and 4\u2010variable remission led to less radiographic progression than PtGA near remission, but without a statistically significant difference. Both 4\u2010variable remission and 3\u2010variable remission appear to be useful targets when aiming for structural nonprogression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24237","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T15:46:10Z","timestamp":1588002370000},"page":"1300-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patient Global Assessment of Disease Activity and Radiographic Progression in Early Arthritis: Three\u2010Year Results From the ESPOIR Cohort"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-0247","authenticated-orcid":false,"given":"Ricardo J. O.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Centro Hospitalar e Universit\u00e1rio de Coimbra and Nursing School of Coimbra (ESEnfC)  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-4274","authenticated-orcid":false,"given":"Bruno","family":"Fautrel","sequence":"additional","affiliation":[{"name":"Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique INSERM Sorbonne Universit\u00e9 and AP\u2010HP Piti\u00e9 Salp\u00eatri\u00e8re Hospital, and CRI IMIDIATE Clinical Research Network  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7067","authenticated-orcid":false,"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[{"name":"CHU Brest and UMR1227, Lymphocytes B et Autoimmunit\u00e9 INSERM Universit\u00e9 de Bretagne occidentale  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-6496","authenticated-orcid":false,"given":"C\u00e9cile","family":"Gaujoux\u2010Viala","sequence":"additional","affiliation":[{"name":"N\u00eemes University Hospital and IDESP Montpellier University  N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-772X","authenticated-orcid":false,"given":"Anne\u2010Christine","family":"Rat","sequence":"additional","affiliation":[{"name":"EA 4360 APEMAC Universit\u00e9 de Lorraine, Nancy, France, and CHU Caen  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-7024","authenticated-orcid":false,"given":"Francis","family":"Guillemin","sequence":"additional","affiliation":[{"name":"EA 4360 APEMAC Universit\u00e9 de Lorraine, and Inserm CIC 1433 Epid\u00e9miologie clinique CHRU de Brabois  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-6780","authenticated-orcid":false,"given":"Jos\u00e9 A. P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Centro Hospitalar e Universit\u00e1rio de Coimbra and University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-6229","authenticated-orcid":false,"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Paris Descartes University H\u00f4pital Cochin Assistance Publique H\u00f4pitaux de Paris, and INSERM (U1153), Paris, France: Clinical epidemiology and biostatistics PRES Sorbonne Paris\u2010Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-310X","authenticated-orcid":false,"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[{"name":"Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique INSERM Sorbonne Universit\u00e9, and AP\u2010HP Piti\u00e9 Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis","volume":"67","author":"Singh JA","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207526"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204339"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23862"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.149765"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1151-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.35"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23866"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex211"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu413"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003554"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.07.003"},{"key":"e_1_2_7_16_1","first-page":"261","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"27","author":"Van der Heijde D","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22078"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.03.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216529"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-3998-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23284"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.24237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:52:03Z","timestamp":1759423923000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/acr.24237"],"URL":"https:\/\/doi.org\/10.1002\/acr.24237","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"2019-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}