{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:26:10Z","timestamp":1789514770881,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Interstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc), and ILD screening, characterization, and monitoring are important for therapeutic decision\u2010making and prognostication. Lung ultrasonography (US) is a potential alternative imaging modality for ILD detection. In this study, our objective was to develop and test a novel lung US examination technique and interpretation criteria for detecting SSc\u2010ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lung US acquisition was performed by collecting short US movies at 14 lung positions. Lung US interpretation criteria for SSc\u2010ILD detection focused on visualized pleural changes. To assess the performance of our methodology for SSc\u2010ILD detection, we prospectively enrolled SSc patients with high\u2010resolution computed tomography (HRCT) imaging within 3 months of lung US. Lung US examinations were scored independently by 2 blinded readers (1 ultrasonographer and 1 nonultrasonographer). The sensitivity and specificity for SSc\u2010ILD detection were assessed, and agreement was measured with Cohen\u2019s kappa statistic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>To test the performance of our lung US acquisition technique and interpretation criteria, 20 SSc patients were evaluated by lung US (278 lung zones) and HRCT. HRCT confirmed ILD in 9 patients (45%). Lung US was positive for SSc\u2010ILD in 11 patients (55%) with a sensitivity of 100% and specificity of 82% versus HRCT, with perfect agreement between the 2 readers (\u03ba = 1). Analysis by individual lung zones found excellent agreement between readers, with 93.8% concordance and \u03ba = 0.82.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed a novel lung US examination technique and interpretation criteria that are highly sensitive and specific for SSc\u2010ILD detection in an SSc cohort, affording perfect agreement between ultrasonographer and nonultrasonographer readers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.24338","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T08:51:23Z","timestamp":1590915083000},"page":"1338-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Development and Assessment of Novel Lung Ultrasound Interpretation Criteria for the Detection of Interstitial Lung Disease in Systemic Sclerosis"],"prefix":"10.1002","volume":"73","author":[{"given":"Robert","family":"Fairchild","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-4910","authenticated-orcid":false,"given":"Melody","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Yang","sequence":"additional","affiliation":[{"name":"Santa Clara Valley Medical Center  Santa Clara California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Sharpless","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine and Palo Alto Health Care System  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000323"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005512"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/2213-0802-2-4"},{"issue":"114","key":"e_1_2_6_7_1","first-page":"165","article-title":"The use of ultrasound for assessing interstitial lung involvement in connective tissue diseases","volume":"36","author":"Ferro F","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1011228"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1409-7"},{"key":"e_1_2_6_10_1","first-page":"S136","article-title":"Pleural irregularity, a new ultrasound sign for the study of interstitial lung disease in systemic sclerosis and antisynthetase syndrome","volume":"33","author":"Pinal\u2010Fernandez I","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3446"},{"key":"e_1_2_6_12_1","first-page":"11","article-title":"Diagnostic accuracy of lung ultrasound for interstitial lung disease in patients with connective tissue diseases: a meta\u2010analysis","volume":"34","author":"Song GG","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1573"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-014-0385-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2513-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_6_17_1","article-title":"Optimizing B\u2010lines on lung ultrasound: an in\u2010vitro to in\u2010vivo pilot study with clinical implications","author":"Schmickl CN","year":"2019","journal-title":"J Clin Monit Comput"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:52:03Z","timestamp":1759423923000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/acr.24338"],"URL":"https:\/\/doi.org\/10.1002\/acr.24338","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}