{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:44:35Z","timestamp":1776095075151,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate changes in health\u2010related quality of life (HRQoL) and disability in children with systemic juvenile idiopathic arthritis (JIA) or polyarticular JIA treated with tocilizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary analyses of two double\u2010blind, placebo\u2010controlled trials of intravenous tocilizumab in children with active systemic JIA or polyarticular JIA were conducted. Patient\u2010reported outcomes of disability (Childhood Health Assessment Questionnaire [C\u2010HAQ]), HRQoL (Child Health Questionnaire Parent Form 50 [CHQ\u2010P50], health concepts, physical summary score [CHQ\u2010P50\u2010PhS], psychosocial summary score [CHQ\u2010P50\u2010PsS]), pain, and well\u2010being (100\u2010mm visual analog scale [VAS]) were measured at weeks 0 and 12 for systemic JIA, weeks 16 and 40 for polyarticular JIA, and week 104 for both JIA subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The trial included 112 patients with systemic JIA and 188 patients with polyarticular JIA. In patients with polyarticular JIA, the mean \u00b1 SD C\u2010HAQ score decreased from 1.39 \u00b1 0.74 at baseline to 0.67 \u00b1 0.65 at week 16 (<jats:italic>P &lt;<\/jats:italic> 0.001). In patients with systemic JIA, the mean \u00b1 SD CHQ\u2010P50\u2010PhS improved more with tocilizumab therapy than with placebo at week 12 (7.3 \u00b1 10.2 versus 2.4 \u00b1 10.6) (<jats:italic>P<\/jats:italic> &lt; 0.05). Almost all mean CHQ\u2010P50 health concept scores, CHQ\u2010P50\u2010PsS, and CHQ\u2010P50\u2010PhS improved (<jats:italic>P<\/jats:italic> \u2264 0.002) by week 104 for patients with systemic JIA. Patients with polyarticular JIA and patients with systemic JIA showed significant reductions in disability (mean \u00b1 SD C\u2010HAQ scores of \u22121.09 \u00b1 0.71 and \u22121.17 \u00b1 0.80, respectively), improvements in well\u2010being (mean \u00b1 SD well\u2010being VAS scores of \u221243.76 \u00b1 26.61 and \u221251.53 \u00b1 23.57, respectively), and decreases in pain (mean \u00b1 SD pain VAS scores of \u221241.56 \u00b1 31.06 and \u221251.26 \u00b1 26.79, respectively) (<jats:italic>P<\/jats:italic> &lt; 0.001); in patients with polyarticular JIA and patients with systemic JIA who were treated with tocilizumab, 92.9% of polyarticular JIA patients and 96.8% of systemic JIA patients reported no more than minimal pain (a score of \u226435 mm on the VAS) at week 104.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tocilizumab treatment was associated with significantly reduced disability and pain and improved HRQoL in patients with systemic JIA and polyarticular JIA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24384","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T13:58:11Z","timestamp":1595512691000},"page":"1264-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Functional Ability and Health\u2010Related Quality of Life in Randomized Controlled Trials of Tocilizumab in Patients With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"first","affiliation":[{"name":"PRCSG Cincinnati Children\u2019s Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"PRCSG Cincinnati Children\u2019s Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-4000","authenticated-orcid":false,"given":"Francesca","family":"Bovis","sequence":"additional","affiliation":[{"name":"University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-8232","authenticated-orcid":false,"given":"Fabrizio","family":"De Benedetti","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Pediatrico Bambino Ges\u00f9  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Espada","sequence":"additional","affiliation":[{"name":"Hospital de Ninos Ricardo Gutierrez  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Joos","sequence":"additional","affiliation":[{"name":"Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Akikusa","sequence":"additional","affiliation":[{"name":"Royal Children\u2019s Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Chaitow","sequence":"additional","affiliation":[{"name":"The Children\u2019s Hospital Westmead  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Lucica","family":"Boteanu","sequence":"additional","affiliation":[{"name":"University Hospital Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-3390","authenticated-orcid":false,"given":"Yukiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Joseph M. 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