{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:15:41Z","timestamp":1774271741509,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early\u2010stage OA development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 294 participants from the Osteoarthritis Initiative (mean \u00b1 SD age 50 \u00b1 3 years; 50% women) with baseline Kellgren\/Lawrence grade of 0 in both knees, all of whom had received knee MRIs at 4 different time points over 6 years (baseline, 24, 48, and 72 months). Using a linear mixed model (knees matched within individuals), we studied whether MRI features (meniscal body extrusion [in mm], cartilage area loss [score 0\u201339], cartilage full thickness loss [range 0\u201316], osteophytes [range 0\u201329], meniscal integrity [range 0\u201310], bone marrow lesions [BMLs] including bone marrow cysts [range 0\u201320], Hoffa\u2010 or effusion\u2010synovitis [absent\/present], and popliteal cysts [absent\/present]) were associated with knee\u2010specific pain as reported on the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire using a 0\u2013100 scale (worst to best).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The differences in KOOS knee pain score for a knee with a 1 unit higher score on MRI were the following: meniscal extrusion \u20131.52 (95% confidence interval [95% CI] \u20132.35, \u20130.69); cartilage area loss \u20130.23 (95% CI \u20130.48, 0.02); cartilage full thickness loss \u20131.04 (95% CI \u20131.58, \u20130.50); osteophytes \u20130.32 (95% CI \u20130.61, \u20130.03); meniscal integrity \u20130.28 (95% CI \u20130.58, 0.02); BMLs including potential cysts \u20130.19 (95% CI \u20130.55, 0.16); synovitis 0.23 (95% CI \u20131.14, 1.60); and popliteal cysts 0.86 (95% CI \u20130.56, 2.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Meniscal extrusion, full thickness cartilage loss, and osteophytes are associated with having more knee pain. Although these features may be relevant targets for future trials, the clinical relevance of our findings is unclear because no feature was associated with a clinically important difference in knee pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24394","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T05:49:53Z","timestamp":1596347393000},"page":"1659-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Relationship Between Magnetic Resonance Imaging Features and Knee Pain Over Six Years in Knees Without Radiographic Osteoarthritis at Baseline"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4851-5794","authenticated-orcid":false,"given":"Karin","family":"Magnusson","sequence":"first","affiliation":[{"name":"Lund University, Lund, Sweden, and Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-2275","authenticated-orcid":false,"given":"Aleksandra","family":"Turkiewicz","sequence":"additional","affiliation":[{"name":"Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaanika","family":"Kumm","sequence":"additional","affiliation":[{"name":"University of Tartu  Tartu Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Englund","sequence":"additional","affiliation":[{"name":"Lund University, Lund, Sweden, and Boston University School of Medicine  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.08.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.04.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2844"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2018.1495164"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.12.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1524"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412993869"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121681"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5339"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24383"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067470"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0639-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3132"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142905"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000541"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-4885-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-64"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-59"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176833"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.131904"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.05.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20672"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.12.023"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200301000-00002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800777"},{"key":"e_1_2_6_31_1","first-page":"565","article-title":"Prevalence of obesity: a comparative survey in France, the United Kingdom and the United States","volume":"16","author":"Laurier D","year":"1992","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31825fa230"}],"container-title":["Arthritis Care &amp; 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