{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:44:58Z","timestamp":1770223498878,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess concordance among criteria for inactive disease (ID) and low disease activity (LDA) in juvenile idiopathic arthritis (JIA) and to seek factors driving discordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The frequency of fulfillment of existing criteria was evaluated in information on 10,186 patients extracted from 3 cross\u2010sectional data sets. Patients were divided up according to the functional phenotypes of oligoarthritis and polyarthritis. Concordance between criteria was examined using weighted Venn diagrams. The role of each individual component in explaining discordance between criteria was assessed by calculating the absolute number and percentage of instances in which the component was responsible for discrepancy between definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Criteria for ID were met by 28.6\u201341.1% of patients with oligoarthritis and by 24.0\u201333.4% of patients with polyarthritis. Criteria for LDA were met by 44.8\u201362.4% of patients with oligoarthritis and by 44.6\u201350.4% of patients with polyarthritis. There was a 57.9\u201362.3% overlap between criteria for ID and a 67.9\u201385% overlap between criteria for LDA. Parent and physician global assessments and acute\u2010phase reactants were responsible for the majority of instances of discordance among criteria for ID (8.7\u201315.5%, 10.0\u201312.3%, and 10.8\u201317.3%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found fair concordance between criteria for ID and LDA in JIA, with the main drivers of discordance for ID being physician and parent global assessments and acute\u2010phase reactants. This observation highlights the need for further studies aimed to evaluate the impact of subjective physician and parent perception of disease remission and of laboratory measures of inflammatory activity on the definition of ID.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24415","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T09:36:27Z","timestamp":1597570587000},"page":"1722-1729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determinants of Discordance Between Criteria for Inactive Disease and Low Disease Activity in Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2558-3559","authenticated-orcid":false,"given":"Gabriella","family":"Giancane","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Genova and IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Campone","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francesca","family":"Gicchino","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Alongi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Bava","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Genova Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-6155","authenticated-orcid":false,"given":"Silvia","family":"Rosina","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaryna","family":"Boyko","sequence":"additional","affiliation":[{"name":"Western Ukrainian Specialized Children\u2019s Medical Centre Lviv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Martin","sequence":"additional","affiliation":[{"name":"The Royal Hospital for Children Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"El Miedany","sequence":"additional","affiliation":[{"name":"Ain Shams University Italian Hospital St. Abbassia Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Harjacek","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Sestre Milosrdnice Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad","family":"Hashad","sequence":"additional","affiliation":[{"name":"Tripoli Children\u2019s Hospital Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maka","family":"Ioseliani","sequence":"additional","affiliation":[{"name":"M. 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