{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:58:39Z","timestamp":1783792719553,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the cumulative articular and extraarticular damage in Arab children with juvenile idiopathic arthritis (JIA) and to identify variables that correlate with disease damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter, cross\u2010sectional study among 14 pediatric rheumatology centers from 7 Arab countries. JIA patients who met the International League of Associations for Rheumatology classification criteria and had a disease duration of &gt;1 year were enrolled. Disease activity status was assessed using the Juvenile Arthritis Multidimensional Assessment Report. Disease damage was assessed by the Juvenile Arthritis Damage Index, articular (JADI\u2010A) and extraarticular (JADI\u2010E).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 702 (471 female) JIA patients with a median age of 11.3 years (interquartile range [IQR] 8.0\u201314.0 years) were studied. Median age at disease onset was 5 years (IQR 2.0\u20139.0 years) and the median disease duration was 4 years (IQR 2.0\u20137.0 years). The most frequent JIA categories were oligoarticular JIA (34.9%), polyarticular JIA (29.5%), and systemic JIA (24.5%). Clinical remission was achieved in 73.9% of patients. At the last clinic visit, 193 patients experienced joint damage, with a mean \u00b1 SD JADI\u2010A score of 1.7 \u00b1 4.5, while 156 patients had extraarticular damage, with a mean \u00b1 SD JADI\u2010E score of 0.5 \u00b1 1.1. Patients with enthesitis\u2010related arthritis had the highest JADI\u2010A score. JADI\u2010A correlated significantly with the presence of a family history of JIA. JADI\u2010A and JADI\u2010E had a significant correlation with long disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cumulative damage was common in this Arab JIA cohort, and consanguinity and JIA in a sibling were frequent findings and were associated with a greater cumulative damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24436","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T14:06:40Z","timestamp":1599228400000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cumulative Damage in Juvenile Idiopathic Arthritis: A\u00a0Multicenter Study From the Pediatric Rheumatology Arab\u00a0Group"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-6698","authenticated-orcid":false,"given":"Sulaiman M.","family":"Al\u2010Mayouf","sequence":"first","affiliation":[{"name":"King Faisal 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