{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:28:03Z","timestamp":1789122483564,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["Unrestricted grant"],"award-info":[{"award-number":["Unrestricted grant"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the impact of inflammation on structural changes occurring in the sacroiliac (SI) joints and the spine detected on magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with early axial spondyloarthritis (SpA) from the Devenir des Spondylarthropathies Indiffer\u00e9renci\u00e9es R\u00e9centes (DESIR) cohort were included. MRIs of the SI joints (MRI\u2010SI joints) and spine (MRI\u2010spine), obtained at baseline, 2\u2009years, and 5\u2009years, were scored by 3 central readers. Inflammation and structural damage on MRI\u2010SI joints and MRI\u2010spine were defined by the agreement of \u22652 of 3 readers (binary outcomes) and by the average of 3 readers (continuous outcomes). The effect of inflammation (MRI\u2010SI joints\/MRI\u2010spine) on damage (MRI\u2010SI joints\/MRI\u2010spine, respectively) was evaluated in 2 models: 1) a baseline prediction model (the effect of baseline inflammation on damage assessed at 5\u2009years); and 2) a longitudinal model (the effect of inflammation on structural damage assessed during a 5\u2010year period).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 202 patients were included. Both the presence of bone marrow edema on MRI\u2010SI joints and on MRI\u2010spine at baseline were predictive of 5\u2010year damage (\u22653 fatty lesions) on MRI\u2010SI joints (odds ratio [OR] 4.2 [95% confidence interval (95% CI) 2.4, 7.3]) and MRI\u2010spine (OR 10.7 [95% CI 2.4, 49.0]), respectively, when adjusted for C\u2010reactive protein level. The association was also confirmed in longitudinal models (when adjusted for Ankylosing Spondylitis Disease Activity Score) both in the SI joints (OR 5.1 [95% CI 2.7, 9.6]) and spine (OR 15.6 [95% CI 4.8, 50.3]). Analysis of other structural outcomes (i.e., erosions) on MRI\u2010SI joints yielded similar results. In the spine, a significant association was found for fatty lesions but not for erosions and bone spurs, which occurred infrequently over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a predictive and longitudinal association between inflammation detected on MRI and several types of structural damage detected on MRI in patients with early axial SpA, which adds to the evidence for a causal relationship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24449","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T18:42:45Z","timestamp":1600281765000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inflammation of the Sacroiliac Joints and Spine and Structural Changes on Magnetic Resonance Imaging in Axial Spondyloarthritis: Five\u2010Year Data From the <scp>DESIR<\/scp> 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