{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:06:24Z","timestamp":1782734784292,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of ixekizumab on self\u2010reported functioning and health in patients with active nonradiographic axial spondyloarthritis (SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>COAST\u2010X was a randomized, controlled trial conducted in patients with nonradiographic axial SpA over 52\u2009weeks. Participants were randomized at a ratio of 1:1:1 to receive 80 mg of ixekizumab subcutaneously every 4\u2009weeks or 2\u2009weeks or placebo for 52\u2009weeks. Self\u2010reported functioning and health end points included the Medical Outcomes Study Short Form 36 (SF\u201036) health survey, Assessment of Spondyloarthritis International Society (ASAS) health index, and European Quality of Life\u20105 Dimensions\u20105 Level (EQ\u20105D\u20105L) health\u2010utility descriptive system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to placebo, ixekizumab treatment resulted in improvement of SF\u201036 physical component summary scores from baseline, with a score of 4.7 improving to 8.9 with ixekizumab therapy every 4\u2009weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and a score of 9.3 with ixekizumab therapy every 2\u2009weeks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01); the greatest improvements were observed in the domains of physical functioning, role\u2010physical, and bodily pain at weeks 16 and 52. A higher proportion of patients receiving ixekizumab therapy every 2\u2009weeks reported \u22653 improvements based on the ASAS health index from baseline to weeks 16 and 52 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Significantly more patients receiving ixekizumab every 4\u2009weeks reported improvements in \u201cgood health status\u201d on the ASAS health index (ASAS score of \u22645) at weeks 16 and 52 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients receiving ixekizumab reported improvements on the EQ\u20105D\u20105L compared to those who received placebo at week 16 (0.11 versus 0.17 for patients receiving treatment every 4\u2009weeks and 0.19 for patients receiving treatment every 2\u2009weeks; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), which remained consistent at week 52. There were no clinical meaningful differences in responses based on the ixekizumab dosing regimen for patients who received ixekizumab therapy every 2\u2009weeks or every 4\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with nonradiographic axial SpA, therapy with ixekizumab was superior to placebo in the improvement of self\u2010reported functioning and health at weeks 16 and 52.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24482","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T14:36:34Z","timestamp":1602513394000},"page":"451-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement of Functioning and Health With Ixekizumab in the Treatment of Active Nonradiographic Axial Spondyloarthritis in a <scp>52\u2010Week<\/scp>, Randomized, Controlled Trial"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-0845","authenticated-orcid":false,"given":"Jessica A.","family":"Walsh","sequence":"first","affiliation":[{"name":"University of Utah School of Medicine and Salt Lake City Veterans Affairs Medical Center  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina N.","family":"Magrey","sequence":"additional","affiliation":[{"name":"MetroHealth Medical Center and Case Western Reserve University School of Medicine  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenofon","family":"Baraliakos","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum Bochum, Germany, and Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Inui","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Yu","family":"Weng","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Medical College and Hospital  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ennio","family":"Lubrano","sequence":"additional","affiliation":[{"name":"University of Molise  Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Boonen","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center and Caphri Research Institute Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne S.","family":"Gensler","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Strand","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum Bochum, Germany, and Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-9175","authenticated-orcid":false,"given":"Theresa","family":"Hunter","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Li","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Marcelino Sandoval","family":"Calderon","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-4497","authenticated-orcid":false,"given":"Uta","family":"Kiltz","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum Bochum, Germany, and Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21994"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.39"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1477591"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.10.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23534"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21688"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41042"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40866"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201766"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204231"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38721"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39257"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000524"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.04.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201933"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S100940"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2018.1410133"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32971-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110767"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208642"},{"issue":"25","key":"e_1_2_9_26_1","first-page":"3130","article-title":"SF\u201036 health survey update","volume":"2000","author":"Ware JE","year":"1976","journal-title":"Spine"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012588218728"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.115550"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104117"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203967"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212076"},{"key":"e_1_2_9_32_1","article-title":"EQ\u20105D value sets: inventory, comparative review and user guide","author":"Szende A OM","year":"2007","journal-title":"Springer"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207596"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22594"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.08.2643"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev267"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:43:45Z","timestamp":1759427025000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,26]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/acr.24482"],"URL":"https:\/\/doi.org\/10.1002\/acr.24482","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,26]]},"assertion":[{"value":"2020-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}