{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:16:11Z","timestamp":1786976171642,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006458","name":"Children's Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether there is a temporal association between arthritis and uveitis activity among children with juvenile idiopathic arthritis\u2013associated uveitis (JIA\u2010U).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Uveitis and arthritis data from patients with JIA\u2010U age\u2009\u226421\u2009years were collected from July 2013 to December 2019 at a tertiary care center. Arthritis activity was assessed at each rheumatology visit, and the primary outcome was the presence of active uveitis at ophthalmologic examination within 45\u2009days of the rheumatology visit. Repeated\u2010measures logistic regression was used to evaluate the temporal association between any uveitis activity within 45\u2009days of arthritis activity. Models were adjusted for demographic\u2010, disease\u2010, and treatment\u2010related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 98 patients were included: 81 (83%) female, 67 (69%) antinuclear antibody positive, 59 (60%) oligoarticular, and 13 (13%) enthesitis\u2010related arthritis (ERA) subtypes. There were 1,229 rheumatology visits, with a median of 13 visits per patient (interquartile range 7\u201318). Concordance between arthritis and uveitis activity was observed 73% of the time (694 of 947). There was an independent temporal association between uveitis and arthritis activity (odds ratio 2.47 [95% confidence interval 1.72\u20133.54];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), adjusted for demographic and disease characteristics. Use of combination biologic and nonbiologic disease\u2010modifying antirheumatic drugs, female sex, HLA\u2013B27 positivity, and ERA and polyarticular (rheumatoid factor negative) subtypes were associated with decreased odds of active uveitis at any time point.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with JIA\u2010U, there is a significant temporal association between arthritis and uveitis disease activity. These novel results suggest that an arthritis flare should prompt an expedited referral to the ophthalmologist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.24483","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T14:46:30Z","timestamp":1602513990000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Temporal Relationship Between Juvenile Idiopathic Arthritis Disease Activity and Uveitis Disease Activity"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-1636","authenticated-orcid":false,"given":"Emily J.","family":"Liebling","sequence":"first","affiliation":[{"name":"The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Faig","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce C.","family":"Chang","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mendoza","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Moore","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine of the University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahomy Ledesma","family":"Vicioso","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Lerman","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.11.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem053"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2003.00066.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27416"},{"key":"e_1_2_6_7_1","first-page":"109","article-title":"Uveitis as a marker of active arthritis in 372 patients with juvenile idiopathic seronegative oligoarthritis or polyarthritis","volume":"20","author":"Kotaniemi K","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2262-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290615"},{"key":"e_1_2_6_10_1","first-page":"1069","article-title":"Validation of the proposed ILAR classification criteria for juvenile idiopathic arthritis: International League of Associations for Rheumatology","volume":"27","author":"Foeldvari I","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh658"},{"key":"e_1_2_6_13_1","first-page":"2446","article-title":"Early predictors of severe course of uveitis in oligoarticular juvenile idiopathic arthritis","volume":"29","author":"Zulian F","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.1.51"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.01.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2019.04.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0088-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key406"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.026955"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10865"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39621"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-018-0156-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17066"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23871"}],"container-title":["Arthritis Care &amp; 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