{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:15:26Z","timestamp":1784621726847,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our primary objective was to study the long\u2010term association between disease activity and disability in axial spondyloarthritis (SpA). Our secondary objective was to define patient profiles according to their level of disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data collected during the first 5\u2009years of follow\u2010up of a large early axial SpA cohort, the Devenir des Spondylarthropathies Indiffer\u00e9nci\u00e9es R\u00e9centes (DESIR) cohort. Multivariable models were built to study the association between the Health Assessment Questionnaire for Ankylosing Spondylitis (HAQ\u2010AS) and the Ankylosing Spondylitis Disease Activity Score with C\u2010reactive protein (ASDAS\u2010CRP), adjusting for potential confounders. Hierarchical multivariable analysis was conducted using the chi\u2010square automatic interaction detector (CHAID) method, to help determine how variables best cluster to explain HAQ\u2010AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 644 patients and 5,152 visits were analyzed. HAQ\u2010AS was longitudinally, independently, and positively associated with ASDAS\u2010CRP (adjusted B [adjB] 0.205 [95% confidence interval (95% CI) 0.187, 0.222]), the enthesitis score (adjB 0.011 [95% CI 0.008, 0.015]), the Bath Ankylosing Spondylitis Metrology Index (adjB 0.087 [95% CI 0.069, 0.105]), and female sex (adjB 0.172 [95% CI 0.120, 0.225]). The CHAID decision tree revealed ASDAS\u2010CRP as the first variable with discriminative power on HAQ\u2010AS. The cutoffs that separated different patient disability profiles were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disease activity contributes longitudinally to disability and is hierarchically superior to any other variable in explaining this health domain. Enthesitis and spinal mobility are also key drivers of disability in early axial SpA. ASDAS\u2010CRP cutoffs that separated different patient disability profiles largely mimicked the cutoffs previously defined for ASDAS\u2010CRP disease activity states.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24515","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T18:12:55Z","timestamp":1605723175000},"page":"768-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>Long\u2010Term<\/scp> Association Between Disease Activity and Disability in Early Axial Spondyloarthritis: Results From a Prospective Observational Study of Inflammatory Back Pain"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-4274","authenticated-orcid":false,"given":"Pedro D.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio do Algarve and Algarve Biomedical Centre, Faro, and Academic Medical Center Universidade 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