{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:17:15Z","timestamp":1779214635228,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005898","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine Vasculaire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the prevalence and clinical correlates of peripheral arterial disease of the upper limbs in patients with systemic sclerosis (SSc), as detected with finger brachial pressure index (FBPI) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This work is based on the baseline data of the SCLEROCAP multicenter cohort of SSc patients. Finger systolic blood pressure was measured with laser Doppler flowmetry, and the FBPI was obtained as its ratio over the ipsilateral brachial systolic blood pressure. An FBPI of &lt;0.70 was used as the diagnostic criterion for occlusive arterial disease of the upper limbs. Thus, the prevalence of defined arterial disease as well as its clinical, biologic, and capillaroscopic correlates were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 326 enrolled patients, 177 (54.3%) met the criterion for arterial disease (FBPI &lt;0.70). No association was found with the type of SSc nor with the type of associated antinuclear antibodies, but a significant association was found with the duration of the disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), the capillaroscopic pattern (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and most strikingly with the presence of digital ulcers (42.9% versus 13.4%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). A quantitative relationship was found between the FBPI and the prevalence of digital ulcers and was shown to be independent from the capillaroscopic pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This cross\u2010sectional study shows a high prevalence of arterial disease of the upper limbs in patients with SSc. FBPI appears to be a strong and independent predictor of digital ulcers. This study suggests that both macro\u2010 and microangiopathy are contributing to the ischemic damage of the fingertips.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24527","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T12:00:29Z","timestamp":1607169629000},"page":"828-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Finger Systolic Blood Pressure Index Measurement: A Useful Tool for the Evaluation of Arterial Disease in Patients With Systemic Sclerosis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-112X","authenticated-orcid":false,"given":"Sophie","family":"Blaise","sequence":"first","affiliation":[{"name":"Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Boulon","sequence":"additional","affiliation":[{"name":"Saint\u2010Andr\u00e9 Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Mangin","sequence":"additional","affiliation":[{"name":"Saint\u2010Andr\u00e9 Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Senet","sequence":"additional","affiliation":[{"name":"Tenon Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Lazareth","sequence":"additional","affiliation":[{"name":"Saint Joseph Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Imbert","sequence":"additional","affiliation":[{"name":"Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois\u2010Xavier","family":"Lapebie","sequence":"additional","affiliation":[{"name":"Rangueil Hospital  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Lacroix","sequence":"additional","affiliation":[{"name":"University Hospital  Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"Constans","sequence":"additional","affiliation":[{"name":"Saint\u2010Andr\u00e9 Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.5.902"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22734"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.03.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.09.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23413"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.07.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X16645854"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863x06072204"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819894774"},{"issue":"119","key":"e_1_2_8_11_1","first-page":"S63","article-title":"Correlation between capillaroscopic classifications and disease severity in systemic sclerosis: results from SCLEROCAP study at inclusion","volume":"37","author":"Boulon C","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_12_1","first-page":"1573","article-title":"Criteria for the classification of early systemic sclerosis","volume":"28","author":"LeRoy EC","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_8_13_1","first-page":"289","article-title":"Early detection of scleroderma\u2010spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon","volume":"9","author":"Maricq HR","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_8_14_1","first-page":"155","article-title":"Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis","volume":"27","author":"Cutolo M","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_8_15_1","first-page":"15","article-title":"Laser Doppler technique for the measurement of digital and segmental systolic blood pressure","volume":"21","author":"Beinder E","year":"1992","journal-title":"Vasa"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104029"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.01.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.11.016"}],"container-title":["Arthritis Care &amp; 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