{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:03:25Z","timestamp":1785305005125,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Myositis\u2010specific antibodies (MSAs) facilitate grouping children with juvenile dermatomyositis (DM) into distinct phenotypes. The first aim of this study was to investigate the link between anti\u2010p155\/140 and lipodystrophy as determined by dual x\u2010ray absorptiometry (DXA) assessment of fat distribution. The second aim was to examine the relationship between anti\u2010p155\/140 and damage to the nailfold capillary system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with juvenile DM followed for a minimum of 5\u2009years were included. The study population was divided into 3 groups (anti\u2010p155\/140, other MSA, and MSA negative). Lipodystrophy was assessed by physician assessment and DXA fat distribution (trunk\u2010to\u2010leg fat ratio). Documentation of nailfold capillary end row loops (ERLs) was obtained at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 subjects (44% anti\u2010p155\/140, 23% other MSA, 33% MSA negative) were included. There was no significant difference in age, disease activity scores, or lipodystrophy between the 3 groups. The trunk\u2010to\u2010leg fat ratios were similar among the 3 groups at different time points. However, the anti\u2010p155\/140 group had significantly decreased ERL counts (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) at baseline as well as a prolonged duration of untreated disease at diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027). Also, the anti\u2010p155\/140 group had fewer patients with a monophasic disease course than the other 2 groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Generalized lipodystrophy frequency was equivalent in all 3 groups based on physician assessments and trunk\u2010to\u2010leg fat ratios. The anti\u2010p155\/140 group had a greater loss of ERLs, suggesting that this MSA may impact the vascular component of juvenile DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24535","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T15:07:24Z","timestamp":1607526444000},"page":"1065-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of p155\/140 Autoantibody With Loss of Nailfold Capillaries but not Generalized Lipodystrophy: A Study of <scp>Ninety\u2010Six<\/scp> Children With Juvenile Dermatomyositis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-4863","authenticated-orcid":false,"given":"Amer","family":"Khojah","sequence":"first","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago and Cure JM Center of Excellence, Stanley Manne Research Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Liu","sequence":"additional","affiliation":[{"name":"Cure JM Center of Excellence, Stanley Manne Research Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia I.","family":"Savani","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Morgan","sequence":"additional","affiliation":[{"name":"Cure JM Center of Excellence, Stanley Manne Research Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Shore","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Bellm","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago and Cure JM Center of Excellence, Stanley Manne Research Center  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpeds.2017.12.053","article-title":"Advances in juvenile dermatomyositis: myositis specific antibodies aid in understanding disease heterogeneity","volume":"195","author":"Pachman LM","year":"2018","journal-title":"J Pediatr"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/rheumatology\/keq407","article-title":"Nailfold capillary density is importantly associated over time with muscle and skin disease activity in juvenile dermatomyositis","volume":"50","author":"Schmeling H","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1542\/peds.83.2.278","article-title":"Childhood dermatomyositis: serial microvascular studies","volume":"83","author":"Silver RM","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_6_5_1","first-page":"1644","article-title":"Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loops","volume":"31","author":"Smith RL","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2017.06.007","article-title":"Autoantibodies in juvenile\u2010onset myositis: their diagnostic value and associated clinical phenotype in a large UK cohort","volume":"84","author":"Tansley SL","year":"2017","journal-title":"J Autoimmun"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MD.0b013e31816bc604","article-title":"Predictors of acquired lipodystrophy in juvenile\u2010onset dermatomyositis and a gradient of severity","volume":"87","author":"Bingham A","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_6_8_1","first-page":"610","article-title":"Lipodystrophy in patients with juvenile dermatomyositis: evaluation of clinical and metabolic abnormalities","volume":"28","author":"Huemer C","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1086\/383573","article-title":"Factors associated with severe impact of lipodystrophy on the quality of life of patients infected with HIV\u20101","volume":"38","author":"Blanch J","year":"2004","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/rheumatology\/kel099","article-title":"The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland): clinical characteristics of children recruited within the first 5 yr","volume":"45","author":"McCann LJ","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1590\/S0100-879X2005000200020","article-title":"Bone mineral density of Brazilian girls with juvenile dermatomyositis","volume":"38","author":"Castro TC","year":"2005","journal-title":"Braz J Med Biol Res"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2334-12-180","article-title":"Lipodystrophy defined by fat mass ratio in HIV\u2010infected patients is associated with a high prevalence of glucose disturbances and insulin resistance","volume":"12","author":"Freitas P","year":"2012","journal-title":"BMC Infect Dis"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.10924","article-title":"Disease activity score for children with juvenile dermatomyositis: reliability and validity evidence","volume":"49","author":"Bode RK","year":"2003","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/art.23299","article-title":"Persistent association of nailfold capillaroscopy changes and skin involvement over thirty\u2010six months with duration of untreated disease in patients with juvenile dermatomyositis","volume":"58","author":"Christen\u2010Zaech S","year":"2008","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/rheumatology\/key257","article-title":"Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies","volume":"58","author":"Kubo S","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/art.23341","article-title":"Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositis","volume":"59","author":"Rouster\u2010Stevens KA","year":"2008","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:30:57Z","timestamp":1759422657000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/acr.24535"],"URL":"https:\/\/doi.org\/10.1002\/acr.24535","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"assertion":[{"value":"2020-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}