{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:12:42Z","timestamp":1783977162020,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is a lack of real\u2010life studies on interleukin\u201017 (IL\u201017) inhibition in psoriatic arthritis (PsA). We assessed real\u2010life 6\u2010 and 12\u2010month effectiveness (i.e., retention, remission, low disease activity [LDA], and response rates) of the IL\u201017 inhibitor secukinumab in PsA patients overall and across 1) number of prior biologic\/targeted synthetic disease\u2010modifying antirheumatic drugs (b\/tsDMARDs), 2) years since diagnosis, and 3) European registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen quality registries in rheumatology participating in the European Spondyloarthritis Research Collaboration Network provided longitudinal, observational data collected as part of routine care for secondary use. Data were pooled and analyzed with Kaplan\u2010Meier plots, log rank tests, Cox regression, and multiple linear and logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,017 PsA patients started treatment with secukinumab between 2015 and 2018. Overall secukinumab retention rates were 86% and 76% after 6 and 12 months, respectively. Crude (LUNDEX adjusted) 6\u2010month remission\/LDA (LDA including remission) rates for the 28\u2010joint Disease Activity Index for Psoriatic Arthritis, the Disease Activity Score in 28 joints using the C\u2010reactive protein level, and the Simplified Disease Activity Index (SDAI) were 13%\/46% (11%\/39%), 36%\/55% (30%\/46%), and 13%\/56% (11%\/47%), and 12\u2010month rates were 11%\/46% (7%\/31%), 39%\/56% (26%\/38%), and 16%\/62% (10%\/41%), respectively. Clinical Disease Activity Index remission\/LDA rates were similar to the SDAI rates. Six\u2010month American College of Rheumatology 20%\/50%\/70% improvement criteria responses were 34%\/19%\/11% (29%\/16%\/9%); 12\u2010month rates were 37%\/21%\/11% (24%\/14%\/7%). Secukinumab effectiveness was significantly better for b\/tsDMARD\u2010naive patients, similar across time since diagnosis (&lt;2\/2\u20134\/&gt;4\u2009years), and varied significantly across the European registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large real\u2010world study on secukinumab treatment in PsA, 6\u2010 and 12\u2010month effectiveness was comparable to that in previous observational studies of tumor necrosis factor inhibitors. Retention, remission, LDA, and response rates were significantly better for b\/tsDMARD\u2010naive patients, were independent of time since diagnosis, and varied significantly across the European countries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24560","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T13:46:00Z","timestamp":1610977560000},"page":"1205-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Real\u2010World Six\u2010 and Twelve\u2010Month Drug Retention, Remission, and Response Rates of Secukinumab in 2,017 Patients With Psoriatic Arthritis in Thirteen European Countries"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-2840","authenticated-orcid":false,"given":"Brigitte","family":"Michelsen","sequence":"first","affiliation":[{"name":"Rigshospitalet, Glostrup, Denmark, Hospital of Southern Norway Trust, Kristiansand, Norway, and Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Georgiadis","sequence":"additional","affiliation":[{"name":"Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Di Giuseppe","sequence":"additional","affiliation":[{"name":"Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne G.","family":"Loft","sequence":"additional","affiliation":[{"name":"DANBIO Registry and Rigshospitalet, Glostrup, Denmark, and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Geneva University Hospital  Geneva 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K.","family":"Eklund","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital and ORTON Orthopaedic Hospital of the Orton Foundation  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-3093","authenticated-orcid":false,"given":"Tore K.","family":"Kvien","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-1365","authenticated-orcid":false,"given":"Maria J.","family":"Santos","sequence":"additional","affiliation":[{"name":"Reuma.pt Registry and Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Gudbjornsson","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology Research (ICEBIO) University Hospital and University of Iceland  Reykjavik 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