{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:38Z","timestamp":1790007338640,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102258"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102258"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102259"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102260"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102261"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102261"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102262"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN2682010000 21C"],"award-info":[{"award-number":["HHSN2682010000 21C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was undertaken to assess whether the odds for incident radiographic osteoarthritis (OA) differ between men and women in regard to body mass index (BMI) and inflammatory magnetic resonance imaging (MRI) markers 1 and 2\u2009years prior, and whether the presence of inflammation on MRI differs between normal\u2010weight and overweight\/obese individuals who develop radiographic OA up to 4\u2009years prior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 355 knees from the Osteoarthritis Initiative study that developed incident radiographic OA and 355 matched controls. MRIs were read for effusion\u2010synovitis and Hoffa\u2010synovitis for up to 4 consecutive annual time points. Subjects were classified as normal\u2010weight (BMI &lt;25), overweight (BMI \u226525 and &lt;30), or obese (BMI \u226530). Conditional logistic regression was used to assess odds of incident radiographic OA for effusion\u2010synovitis and Hoffa\u2010synovitis at 1 and 2\u2009years prior to radiographic OA incidence (i.e., \u201cP\u20101\u201d and \u201cP\u20102\u201d) considering BMI category. Bivariate logistic regression was used to assess odds of inflammation for cases only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010eight (25.1%) participants were normal weight, 283 (39.9%) overweight, and 249 (35.1%) obese. At P\u20102, being overweight with Hoffa\u2010synovitis, which had an odds ratio [OR] of 3.26 (95% confidence interval [95% CI] 1.39\u22127.65), or effusion\u2010synovitis (OR 3.56 [95% CI 1.45\u20138.75]) was associated with greater odds of incident radiographic OA in women. For those with incident radiographic OA, there were no increased odds of synovitis in the overweight\/obese subgroup for most time points, but increased odds for effusion\u2010synovitis were observed at P\u20102 (OR 2.21 [95% CI 1.11\u20134.43]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presence of inflammatory markers seems to play a role especially in overweight women, while obese women have increased odds for radiographic OA also in the absence of these markers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24568","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T19:43:11Z","timestamp":1612381391000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Presence of Magnetic Resonance Imaging\u2013Defined Inflammation Particularly in Overweight and Obese Women Increases Risk of Radiographic Knee Osteoarthritis: The POMA Study"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7350","authenticated-orcid":false,"given":"Frank W.","family":"Roemer","sequence":"first","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and VA Boston Healthcare System, West Roxbury  Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Hannon","sequence":"additional","affiliation":[{"name":"(current address: Pinney Associates, Pittsburgh, Pennsylvania), (current address: The University of Tokyo, Tokyo, Japan), (current address: University of Arizona College of Medicine, Tucson) University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fujii","sequence":"additional","affiliation":[{"name":"(current address: Pinney Associates, Pittsburgh, Pennsylvania), (current address: The University of Tokyo, Tokyo, Japan), (current address: University of Arizona College of Medicine, Tucson) University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Omoumi","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-752X","authenticated-orcid":false,"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital and Institute of Bone and University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2014-8278","authenticated-orcid":false,"given":"Felix","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Salzburg and Nuremberg  Salzburg, Austria, and Chondrometrics Ainring Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-550X","authenticated-orcid":false,"given":"C. Kent","family":"Kwoh","sequence":"additional","affiliation":[{"name":"(current address: Pinney Associates, Pittsburgh, Pennsylvania), (current address: The University of Tokyo, Tokyo, Japan), (current address: University of Arizona College of Medicine, Tucson) University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24337"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33332"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40087"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23698"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7242478"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.03.014"},{"key":"e_1_2_8_8_1","first-page":"464","article-title":"Association between metabolic syndrome and knee osteoarthritis: a cross\u2010sectional nationwide survey study","volume":"51","author":"Lee BJ","year":"2019","journal-title":"J Rehabil Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.016"},{"key":"e_1_2_8_11_1","unstructured":"Osteoarthritis Initiative.Appendix A. 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