{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:33:08Z","timestamp":1790663588394,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015629","name":"Jerome L. Greene Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010053503"],"award-info":[{"award-number":["P30\u2010AR\u2010053503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1\u2010DE12354\u201015A1"],"award-info":[{"award-number":["RO1\u2010DE12354\u201015A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess anti\u2010Ro52 and anti\u2010Ro60 serologic profiles as markers of clinically relevant phenotypic subsets of patients with Sj\u00f6gren's syndrome (SS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a cohort of 839 consecutive patients with suspected or established SS seen in our multidisciplinary SS center, we compared the association of key phenotypic features in 390 patients who fulfilled SS classification criteria and in the parent cohort, stratifed by the presence of both anti\u2010Ro60 and anti\u2010Ro52, anti\u2010Ro60 alone, and anti\u2010Ro52 alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SS cohort included 227 patients (58%) with both anti\u2010Ro60 and anti\u2010Ro52, 65 (17%) with anti\u2010Ro60 alone, 58 (15%) with anti\u2010Ro52 alone, and 40 (10%) with neither antibody. Those with both anti\u2010Ro60 and anti\u2010Ro52 had a significantly increased prevalence of abnormal ocular surface staining, focal lymphocytic sialadenitis with focus score\u2009\u22651, antinuclear antibody \u22651:320, anti\u2010SSB\/La, rheumatoid factor, and IgG \u226515.6 gm\/liter (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0016 for all). The groups with isolated anti\u2010Ro52 and anti\u2010Ro60 were equivalent to each other in their phenotypic associations, except for rheumatoid factor, which was higher in the anti\u2010Ro52 alone group. The associations of these Ro antibody serologic profiles were similar in the parent cohort, except for additional associations with salivary gland enlargement and parotid gland ultrasound score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SS patients with both anti\u2010Ro60 and anti\u2010Ro52 antibodies are distinguished by a higher prevalence of markers of B\u2010cell hyperactivity and glandular inflammation. Antibody reactivity to both Ro60 and Ro52 may thus serve as an important inclusion criterion for SS patients in clinical trials where the therapeutic agent targets pathways mediating these pathogenic abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24597","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T06:10:29Z","timestamp":1616220629000},"page":"1559-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Antibodies to Both Ro52 and Ro60 for Identifying Sj\u00f6gren's Syndrome Patients Best Suited for Clinical Trials of <scp>Disease\u2010Modifying<\/scp> Therapies"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-059X","authenticated-orcid":false,"given":"Berkan","family":"Arma\u011fan","sequence":"first","affiliation":[{"name":"Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Bazoberry","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Perin","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Grader\u2010Beck","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen K.","family":"Akpek","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Kim","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-013X","authenticated-orcid":false,"given":"Alan N.","family":"Baer","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/606195"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340613"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199902)42:2<199::AID-ANR1>3.0.CO;2-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.10.929"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/978202"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39859"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310000-00008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.09.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22264"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2014-000022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2376::AID-ART402>3.0.CO;2-E"},{"issue":"126","key":"e_1_2_7_13_1","first-page":"134","article-title":"Anti\u2010Ro52 and\/or anti\u2010Ro60 immune reactivity: autoantibody and disease associations","volume":"38","author":"Zampeli E","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00444"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.732131"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/415272"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201381"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13508"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30381"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.07.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21956"},{"key":"e_1_2_7_22_1","first-page":"349","article-title":"Lower prevalence of extra\u2010glandular manifestations and anti\u2010SSB antibodies in patients with primary Sjogren's syndrome and widespread pain: evidence for a relatively benign subset","volume":"32","author":"Ter Borg EJ","year":"2014","journal-title":"Clin Exp Rheumatol"}],"container-title":["Arthritis Care &amp; 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