{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:03:38Z","timestamp":1769011418373,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate health care costs associated with biologic disease\u2010modifying antirheumatic drugs (bDMARDs) in a German real\u2010world cohort of adult biologics\u2010naive patients with psoriatic arthritis (PsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Claims data from the Institute for Applied Health Research Berlin (InGef) research database for patients with a PsA diagnosis and bDMARD claims record (index date) between January 1, 2014, and December 31, 2017, and no bDMARD prescriptions for 365\u2009days before the index date were retrospectively analyzed. Primary outcomes were determination of health care resource utilization and associated annual health care costs for overall and individual bDMARDs in the 12\u2010month pre\u2010index and post\u2010index periods. These outcomes were compared between persistent and nonpersistent groups. Nonpersistence was defined as treatment gap or switch to a bDMARD other than the index therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 10,954 patients with a PsA diagnosis, 348 were eligible. Although mean\u2009\u00b1\u2009SD post\u2010index costs were significantly higher in the persistent group than the nonpersistent group (\u20ac27,869\u2009\u00b1\u20098,001 versus \u20ac21,897\u2009\u00b1\u200910,600, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090 .001) due to higher bDMARD acquisition costs (\u20ac23,996\u2009\u00b1\u20094,818 versus \u20ac16,427\u2009\u00b1\u20099,033, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), persistence reduced inpatient treatment costs (\u2013\u20ac760), outpatient treatment costs (\u2013\u20ac192), other drug costs (\u2013\u20ac724), and sick leave costs (\u2013\u20ac601).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although initiation of bDMARDs increased the total health care costs irrespective of persistence status, partial cost offsets were observed in the persistent patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24598","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T06:20:40Z","timestamp":1616221240000},"page":"1435-1443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health Resource Utilization and Associated Health Care Costs of Biologic <scp>Disease\u2010Modifying<\/scp> Antirheumatic Drugs in German Patients With Psoriatic Arthritis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-6207","authenticated-orcid":false,"given":"Philipp","family":"Sewerin","sequence":"first","affiliation":[{"name":"University Hospital of D\u00fcsseldorf, Heinrich\u2010Heine University  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Borchert","sequence":"additional","affiliation":[{"name":"Xcenda  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Meise","sequence":"additional","affiliation":[{"name":"Xcenda  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[{"name":"University Hospital of D\u00fcsseldorf, Heinrich\u2010Heine University  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Mahlich","sequence":"additional","affiliation":[{"name":"Janssen, Neuss, Germany, and D\u00fcsseldorf Institute of Competition Economics, University of D\u00fcsseldorf  Dusseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8630-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214065"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0263-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160180"},{"key":"e_1_2_9_7_1","first-page":"A566","article-title":"Epidemiology and costs of psoriatic arthritis in Germany: a retrospective claims data analysis","volume":"19","author":"Jacob C","year":"2016","journal-title":"Value Health"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/ddg.13464","article-title":"Analysis of pharmaceutical care in patients with psoriatic arthritis using statutory health insurance data","volume":"16","author":"Sondermann W","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez383"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217159"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S56073"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1631798"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3423-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3825-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2017.16272"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2018.24.7.654"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00213.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3348-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4194-y"},{"key":"e_1_2_9_20_1","unstructured":"Destatis Statistisches Bundesamt.Ergebnisse der bev\u00f6lkerungsfortschreibung auf grundlage des zensus2011. 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