{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:42:39Z","timestamp":1761061359117,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102258","N01\u2010AR\u20102\u20102259","N01\u2010AR\u20102\u20102260","N01\u2010AR\u20102\u20102261","N01\u2010AR\u20102\u20102262","R01AR066601"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102258","N01\u2010AR\u20102\u20102259","N01\u2010AR\u20102\u20102260","N01\u2010AR\u20102\u20102261","N01\u2010AR\u20102\u20102262","R01AR066601"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN2682010000 21C"],"award-info":[{"award-number":["HHSN2682010000 21C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Objective<\/jats:title>To describe compartmental frequencies of magnetic resonance image (MRI<\/jats:styled-content>)\u2013defined osteophytes and co\u2010localized cartilage damage and evaluate the associations of osteophyte size with any ipsicompartmental cartilage damage in knees with incident tibiofemoral radiographic knee osteoarthritis (OA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We evaluated knees from the Osteoarthritis Initiative without radiographic knee OA<\/jats:styled-content> at baseline that developed radiographic knee OA<\/jats:styled-content> during a 4\u2010year interval. Semiquantitative MRI<\/jats:styled-content> scoring of osteophytes and cartilage damage was performed at the time point when radiographic knee OA<\/jats:styled-content> was diagnosed, defined as Kellgren\/Lawrence<\/jats:styled-content> grade of \u22652, using the MRI<\/jats:styled-content> Osteoarthritis Knee Score instrument. The frequencies of maximum osteophyte size and maximum grade of ipsicompartmental (i.e., patellofemoral, medial tibiofemoral, lateral tibiofemoral, posterior femur) cartilage damage were assessed. Generalized estimating equations were used to determine the association of MRI<\/jats:styled-content>\u2010defined maximum osteophyte size with presence of any (excluding focal superficial defects) ipsicompartmental cartilage damage.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 296 knees that did not have tibiofemoral radiographic knee OA<\/jats:styled-content> at the baseline visit but developed radiographic knee OA<\/jats:styled-content> during the 48\u2010month observational period were included. In the patellofemoral, medial tibiofemoral, and lateral tibiofemoral compartments, the most frequent osteophyte grade was 1 (67.6%, 59.1%, and 51.7%, respectively) and was 0 (51.7%) in the posterior femur. For all compartments except the posterior femur, a linear trend was found between increasing maximum osteophyte size and the presence of any concomitant cartilage damage.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this sample of knees with incident tibiofemoral radiographic knee OA<\/jats:styled-content>, the patellofemoral joint showed more severe cartilage damage than other compartments regardless of concomitant osteophyte size. In the posterior femur, cartilage damage was rare despite the presence or size of concomitant osteophytes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24605","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T12:03:35Z","timestamp":1616760215000},"page":"1513-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Magnetic Resonance Imaging\u2013Defined Osteophyte Presence and Concomitant Cartilage Damage in Knees With Incident Tibiofemoral Osteoarthritis: Data From the Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses Study"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-3800","authenticated-orcid":false,"given":"James","family":"MacKay","sequence":"first","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, UK, and University of Cambridge School of Clinical Medicine Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and VA Boston Healthcare System West Roxbury Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Kent","family":"Kwoh","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine Tucson"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L. Paul","family":"See","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and Khoo Teck Puat Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Jarraya","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Pfizer New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Hannon","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, and Pinney Associates Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fuji","sequence":"additional","affiliation":[{"name":"The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7350","authenticated-orcid":false,"given":"Frank W.","family":"Roemer","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, Massachusetts, and Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg & Universit\u00e4tsklinikum Erlangen Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5339"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.07.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.7.401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33344"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39176"},{"key":"e_1_2_7_9_1","unstructured":"Osteoarthritis Initiative.Central reading of knee x\u2010rays for Kellgren & Lawrence grade and individual radiographic features of tibiofemoral knee OA. 2016. 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