{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:49:55Z","timestamp":1781077795203,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to quantify costs of hospital\u2010associated care for juvenile idiopathic arthritis (JIA), provide insights in patient\u2010level variation in costs, and investigate costs over time from the moment of JIA diagnosis. Results were reported for all JIA patients in general and by subtype.\u2003<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a single\u2010center, retrospective analysis of prospective data from electronic medical records of children with JIA, ages 0\u201318\u2009years, between April 1, 2011 and March 31, 2019. Patient characteristics (age, sex, JIA subtype) and hospital\u2010based resource use (consultations, medication, radiology procedures, laboratory testing, surgeries, emergency department [ED] visits, hospital stays) were extracted and analyzed. Unit prices were obtained from Dutch reimbursement lists and pharmaceutical and hospital list prices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 691 patients. The mean total cost of hospital care was \u20ac3,784\/patient\/year, of which \u20ac2,103 (55.6%) was attributable to medication. Other costs involved pediatric rheumatologist visits (\u20ac633\/patient\/year [16.7%]), hospital stays (\u20ac439\/patient\/year [11.6%]), other within\u2010hospital specialist visits (\u20ac324\/patient\/year [8.6%]), radiology procedures (\u20ac119\/patient\/year [3.1%]), laboratory tests (\u20ac114\/patient\/year [3.0%]), surgeries (\u20ac46\/patient\/year [1.2%]), and ED visits (\u20ac6\/patient\/year [0.2%]). Mean annual total costs varied between JIA subtypes and between individuals and were the highest for systemic JIA (\u20ac7,772\/patient\/year). Over the treatment course, costs were the highest in the first month after JIA diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospital care costs of JIA vary substantially between individuals, between subtypes, and over the treatment course. The highest annual costs were for systemic JIA, primarily attributable to medication (i.e., biologics). Costs of other hospital\u2010associated care were comparable regardless of subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24621","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:26:57Z","timestamp":1620008817000},"page":"1585-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Costs of <scp>Hospital\u2010Associated<\/scp> Care for Patients With Juvenile Idiopathic Arthritis in the Dutch Health Care System"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-6789","authenticated-orcid":false,"given":"Michelle M. 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