{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:56:02Z","timestamp":1791705362766,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000033","name":"Institute of Musculoskeletal Health and Arthritis","doi-asserted-by":"publisher","award":["PAF\u2010107513"],"award-info":[{"award-number":["PAF\u2010107513"]}],"id":[{"id":"10.13039\/501100000033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Discovery Grant #05246"],"award-info":[{"award-number":["Discovery Grant #05246"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["Discovery Grant #06347"],"award-info":[{"award-number":["Discovery Grant #06347"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","award":["TGP\u201018\u20100229"],"award-info":[{"award-number":["TGP\u201018\u20100229"]}],"id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Bone marrow lesions (BMLs) are associated with painful and progressive osteoarthritis (OA). Quantitative magnetic resonance imaging (MRI) has been used to study early cartilage degeneration in knees with BML, but similar work has not been done in hips. The purpose of this study was to compare mean delayed gadolinium\u2010enhanced MRI of cartilage (dGEMRIC) relaxation values (T1Gd) in hips with BML to hips without BML in a population\u2010based study. Reduced T1Gd suggests depleted glycosaminoglycan. Our hypothesis was that mean T1Gd is lower in hips with BML compared to hips without BML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study participants (n\u00a0=\u00a0128) were recruited from a cross\u2010sectional population\u2010based study of people ages 20\u201349\u2009years with and without hip pain. dGEMRIC and proton density (PD)\u2013weighted MRI scans of 1 hip from each participant were used for this analysis. BMLs were identified from PD\u2010weighted fat\u2010suppressed images. We applied a sampling\u2010weighted linear regression model to determine the association of the presence of BMLs with mean cartilage T1Gd (significance: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The model was adjusted for age, sex, body mass index (BMI), hip pain, cam\/pincer deformity, and physical activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two (25%) of the 128 participants had at least 1 BML. Subjects with at least 1 BML, compared to those without, had similar weighted characteristics of age, BMI, physical activity levels, and frequency of hip pain. Mean T1Gd was 75.25 msec lower (95% confidence interval \u2013149.69, \u20130.81; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) (9%) in the BML compared to the no\u2010BML group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that hips with BMLs are associated with hip cartilage degeneration early in the OA disease process.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24733","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T01:24:42Z","timestamp":1623893082000},"page":"1997-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Delayed Gadolinium\u2010Enhanced Magnetic Resonance Imaging of Cartilage Values in Hips With Bone Marrow Lesions"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-0010","authenticated-orcid":false,"given":"Carly 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Arthritis Research Canada  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Russell","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce B.","family":"Forster","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Health Evaluation and Outcome Sciences  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Esdaile","sequence":"additional","affiliation":[{"name":"Arthritis Research 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