{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:40:15Z","timestamp":1788964815439,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009157","name":"National Institute on Disability, Independent Living, and Rehabilitation Research","doi-asserted-by":"publisher","award":["90ARCP0003"],"award-info":[{"award-number":["90ARCP0003"]}],"id":[{"id":"10.13039\/100009157","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018950","name":"Centre Hospitalier Universitaire de Rennes","doi-asserted-by":"publisher","award":["CORECT Visiting Grant 2020"],"award-info":[{"award-number":["CORECT Visiting Grant 2020"]}],"id":[{"id":"10.13039\/501100018950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24\u2010AR\u2010063129"],"award-info":[{"award-number":["K24\u2010AR\u2010063129"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically review evidence of rehabilitation interventions for improving outcomes in systemic sclerosis (SSc) and to evaluate evidence quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Several electronic databases were searched to identify studies in which rehabilitation professionals delivered, supervised, or participated in interventions for individuals with SSc. Randomized controlled trials (RCTs) or non\u2010randomized trials, one\u2010arm trials, and prospective quasi\u2010experimental studies with interventions were included if they had \u226510 participants. Quality appraisal was conducted by 2 independent raters using the Physiotherapy Evidence Database (PEDro) Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 good or excellent quality studies (15 RCTs, 1 prospective quasi\u2010experimental study) were included. Most rehabilitation interventions focused on hands\/upper extremities, followed by multicomponent, orofacial, and directed self\u2010management. Sample sizes varied between 20\u2013267 participants (median 38). In 50% of studies, participants in intervention groups significantly improved compared to controls. Most studies demonstrated within\u2010group improvements in intervention groups. Interventions varied in content, delivery, length, and dose and outcome measures collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Existing evidence provides some support for rehabilitation in SSc, such as interventions that focus on hand and upper extremity outcomes or are multicomponent, although there is high study heterogeneity. The evidence base would benefit from interventions testing similar replicable components, use of common outcome measures, and incorporation of delivery modes that enable larger sample sizes. There are challenges in recruiting participants due to the rarity of SSc and high disease burden, as participants' involvement in rehabilitation studies requires active participation over time. Intervention studies designed to reduce participation barriers may facilitate translation of effective interventions into practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24737","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T01:29:55Z","timestamp":1624498195000},"page":"59-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Rehabilitation Interventions in Systemic Sclerosis: A Systematic Review and Future Directions"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-0012","authenticated-orcid":false,"given":"Susan L.","family":"Murphy","sequence":"first","affiliation":[{"name":"University of Michigan and VA Ann Arbor Healthcare System  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-5707","authenticated-orcid":false,"given":"Janet 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