{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:39:44Z","timestamp":1761514784453,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>As first\u2010degree relatives (FDRs) of HLA\u2013B27\u2013positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1\u2009year of follow\u2010up, and 2) to describe the evolution toward clinical disease within 1\u2009year of follow\u2010up in a cohort of seemingly healthy FDRs of HLA\u2013B27\u2013positive axial SpA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Pre\u2010SpA cohort is a 5\u2010year prospective inception cohort of seemingly healthy FDRs of HLA\u2013B27\u2013positive axial SpA patients. Clinical and imaging features were collected and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 19% of the FDRs reported inflammatory back pain, 32% current arthralgia, 3% arthritis (ever), 5% enthesitis (ever), and 1% dactylitis (ever), and 3% had an extraarticular manifestation. C\u2010reactive protein level was elevated in 16%, and erythrocyte sedimentation rate was elevated in 7%. On magnetic resonance imaging (MRI) views of sacroiliac joints, 10% had a Spondyloarthritis Research Consortium of Canada score of \u22652, 4% had a score of \u22655, and 4% had deep lesions. In total, 1% fulfilled the modified New York criteria for radiographic sacroiliitis. Clinical, MRI, and acute phase findings were equally distributed between HLA\u2013B27\u2013positive and \u2013negative FDRs. After 1\u2009year of follow\u2010up, clinical parameters did not change on the group level, but 6% of the FDRs were clinically diagnosed with axial SpA, of whom 86% were HLA\u2013B27\u2013positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Features associated with SpA or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA\u2013B27\u2013positive and \u2013negative FDRs. Progression to clinical axial SpA within 1\u2009year of follow\u2010up was mainly observed in HLA\u2013B27\u2013positive FDRs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24743","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T03:05:45Z","timestamp":1625454345000},"page":"2076-2084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Progression From Subclinical Inflammation to Overt Spondyloarthritis in First\u2010Degree Relatives of Patients in Association With HLA\u2013B27: The Pre\u2010Spondyloarthritis Cohort"],"prefix":"10.1002","volume":"74","author":[{"given":"Henri\u00ebtte M. Y.","family":"de Jong","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Academic Medical Center\/University of Amsterdam, and Amsterdam Rheumatology and Immunology Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke J. H.","family":"de Winter","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Academic Medical Center\/University of Amsterdam, and Amsterdam Rheumatology and Immunology Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene E.","family":"van der Horst\u2010Bruinsma","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, and VU University Medical Centre  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk\u2010Jan","family":"van Schaardenburg","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Academic Medical Center\/University of Amsterdam, Amsterdam Rheumatology and Immunology Center, and Reade  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-7407","authenticated-orcid":false,"given":"Floris A.","family":"van Gaalen","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"van Tubergen","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center and Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelique E. A. M.","family":"Weel","sequence":"additional","affiliation":[{"name":"Maasstad Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B. M.","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Academic Medical Center\/University of Amsterdam, and Amsterdam Rheumatology and Immunology Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique L. P.","family":"Baeten","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Academic Medical Center\/University of Amsterdam, and Amsterdam Rheumatology and Immunology Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen G. 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