{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:21:41Z","timestamp":1792448501370,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["OCAY\u201018\u2010774\u2010OFIL"],"award-info":[{"award-number":["OCAY\u201018\u2010774\u2010OFIL"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"Objective<\/jats:title>While interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc), there remains a paucity of predictive markers to assess disease progression. We previously demonstrated that adipose tissue metabolism and adipokine homeostasis is dysregulated in SSc. The present study was undertaken to determine the association and predictive ability of the novel adipokine C1q\/tumor necrosis factor\u2013related protein 9 (CTRP9) for SSc\u2010associated ILD.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a retrospective longitudinal study utilizing the Northwestern Scleroderma Program Patient Registry and Biorepository. Serum levels of CTRP9 were measured in 110 SSc patients at baseline, and demographic, clinical, and pulmonary function test data were collected in 12\u2010month intervals to 48 months. Longitudinal trajectory of forced vital capacity percent predicted (FVC%) was used as a primary outcome measure. We utilized a mixed model to compare trajectories of lung function by CTRP9 groups and performed latent trajectory analysis to accommodate for heterogeneity.<\/jats:p><\/jats:sec>Results<\/jats:title>In cross\u2010sectional analysis, elevated circulating CTRP9 was associated with significantly lower FVC% at baseline (72%\u2009\u00b1\u200917 versus 80%\u2009\u00b1\u200918; P<\/jats:italic>\u00a0=\u00a00.02) and 48 months (68\u2009\u00b1\u200919 versus 84\u2009\u00b1\u200918; P<\/jats:italic>\u00a0=\u00a00.001). In mixed model analysis, high CTRP9 was associated with worse lung function but not with a different trajectory (P<\/jats:italic>\u00a0=\u00a00.23). In contrast, low CTRP9 identified patients with stability of lung disease with reasonable accuracy (sensitivity 73%). Latent trajectory analysis confirmed the association of lower CTRP9 with higher FVC%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Higher circulating CTRP9 associated with worse pulmonary function, while low CTRP9 identified patients with lung disease stability over time. These findings suggest that CTRP9 may be a potential biomarker in SSc\u2010associated ILD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24749","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:46:41Z","timestamp":1626079601000},"page":"152-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis\u2013Associated Interstitial Lung Disease"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-3648","authenticated-orcid":false,"given":"Monica M.","family":"Yang","sequence":"first","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Balmert","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Goncalves","family":"Marangoni","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Carns","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-9890","authenticated-orcid":false,"given":"Monique","family":"Hinchcliff","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-2628","authenticated-orcid":false,"given":"Benjamin D.","family":"Korman","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall AJ","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/art.38990","article-title":"Myofibroblasts in murine cutaneous fibrosis originate from adiponectin\u2010positive intradermal progenitors","volume":"67","author":"Marangoni RG","year":"2015","journal-title":"Arthritis 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