{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:33:50Z","timestamp":1768487630373,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence and potential risk factors for polypharmacy and prescribing of the potentially inappropriate medications, opioids and benzodiazepines\/Z\u2010drugs, in older adults with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised adults age\u2009\u226550\u2009years meeting American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria followed at a tertiary care rheumatology clinic. Information on prescriptions filled in the 4 months preceding chart review was obtained from the Manitoba Drug Program Information Network. Clinical data, including age, sex, Charlson Comorbidity Index (CCI) score, Systemic Lupus Erythematosus Disease Activity Index 2000 score, prednisone use, SLE duration, and rural residence were abstracted from electronic medical records. Logistic regression analyses were performed to assess any association between polypharmacy (using 2 definitions: \u22655 and\u2009\u226510 medications), potentially inappropriate medication use, and clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 206 patients (mean age 62\u2009years, 91% female, 36% rural) were included: 148 (72%) filled \u22655 medications, 71 (35%) filled \u226510 medications, 63 (31%) used benzodiazepines\/Z\u2010drugs, and 50 (24%) used opioids. Among the 77 patients age\u2009\u226565\u2009years, 57 (74%) filled \u22655 medications, and 26 (34%) filled \u226510 medications, compared to 30% and 4%, respectively, of Manitobans age\u2009\u226565\u2009years (National Prescription Drug Utilization Information System, 2016). The odds of polypharmacy were greater with prednisone use (adjusted odds ratio [OR] 3.70 [95% confidence interval (95% CI) 1.40\u20139.79] for \u22655 medications), CCI score (adjusted OR 1.62 [95% CI 1.20\u20132.17]), and rural residence (adjusted OR 2.05 [95% CI 1.01\u20134.18]). Odds of benzodiazepine\/Z\u2010drug use were increased with polypharmacy (adjusted OR 4.35 [95% CI 1.69\u201311.22]), and odds of opioid use were increased with polypharmacy (adjusted OR 6.75 [95% CI 1.93\u201323.69]) and CCI score (adjusted OR 1.29 [95% CI 1.08\u20131.54]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of polypharmacy in this SLE cohort was higher than in the general Manitoban population. Polypharmacy is a strong marker for use of prescription benzodiazepines\/Z\u2010drugs and opioids.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24766","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T03:03:01Z","timestamp":1628478181000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Polypharmacy and Potentially Inappropriate Medication Use in Older Adults With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"75","author":[{"given":"Dale Jean\u2010Guy","family":"S\u00e9guin","sequence":"first","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Peschken","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Dolovich","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby E.","family":"Grymonpre","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D.","family":"St. John","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-525X","authenticated-orcid":false,"given":"Annaliese","family":"Tisseverasinghe","sequence":"additional","affiliation":[{"name":"Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13153"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-016-1451-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.892"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.07.015"},{"key":"e_1_2_6_8_1","unstructured":"Canadian Institute for Health Information.Drug use among seniors in Canada.2016. 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