{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:09:34Z","timestamp":1790374174044,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","award":["Stars Career Development Award (STAR\u201019\u20100610)"],"award-info":[{"award-number":["Stars Career Development Award (STAR\u201019\u20100610)"]}],"id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["New Investigator Award"],"award-info":[{"award-number":["New Investigator Award"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","award":["James McGill Professor of Medicine Award"],"award-info":[{"award-number":["James McGill Professor of Medicine Award"]}],"id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the incidence of and factors associated with SARS\u2013CoV\u20102 testing and infection in immune\u2010mediated inflammatory disease (IMID) patients versus matched non\u2010IMID comparators from the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based, matched cohort study among adult residents from Ontario, Canada, from January 2020 to December 2020. We created cohorts for the following IMIDs: rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis, systemic autoimmune rheumatic diseases, multiple sclerosis (MS), iritis, inflammatory bowel disease (IBD), polymyalgia rheumatica, and vasculitis. Each patient was matched with 5 patients without IMIDs based on sociodemographic factors. We estimated the incidence of SARS\u2013CoV\u20102 testing and infection in IMID patients and non\u2010IMID patients. Multivariable logistic regressions assessed odds of SARS\u2013CoV\u20102 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 493,499 patients with IMIDs and 2,466,946 patients without IMIDs. Patients with IMIDs were more likely to have at least 1 SARS\u2013CoV\u20102 test versus patients without IMIDs (27.4% versus 22.7%), but the proportion testing positive for SARS\u2013CoV\u20102 was identical (0.9% in both groups). Overall, IMID patients had 20% higher odds of being tested for SARS\u2013CoV\u20102 (odds ratio 1.20 [95% confidence interval 1.19\u20131.21]). The odds of SARS\u2013CoV\u20102 infection varied across IMID groups but was not significantly elevated for most IMID groups compared with non\u2010IMID comparators. The odds of SARS\u2013CoV\u20102 infection was lower in IBD and MS and marginally higher in RA and iritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients across all IMIDs were more likely to be tested for SARS\u2013CoV\u20102 versus those without IMIDs. The risk of SARS\u2013CoV\u20102 infection varied across disease subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24781","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T06:57:18Z","timestamp":1630911438000},"page":"317-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Understanding <scp>COVID<\/scp>\u201019 Risk in Patients With <scp>Immune\u2010Mediated<\/scp> Inflammatory Diseases: A <scp>Population\u2010Based<\/scp> Analysis of <scp>SARS<\/scp>\u2013<scp>CoV<\/scp>\u20102 Testing"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-1715","authenticated-orcid":false,"given":"Lihi","family":"Eder","sequence":"first","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Croxford","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Drucker","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Mendel","sequence":"additional","affiliation":[{"name":"McGill University  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindee","family":"Kuriya","sequence":"additional","affiliation":[{"name":"Sinai Health System, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-2076","authenticated-orcid":false,"given":"Zahi","family":"Touma","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-2976","authenticated-orcid":false,"given":"Sindhu R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Toronto Western Hospital, Mount Sinai Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cook","sequence":"additional","affiliation":[{"name":"University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"McGill University  Montreal, Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-4771","authenticated-orcid":false,"given":"Nigil","family":"Haroon","sequence":"additional","affiliation":[{"name":"Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto Western Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Widdifield","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, ICES, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000193605.93416.df"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032487"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8153-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014032"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214844"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goy053"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102523"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.234"},{"key":"e_1_2_6_10_1","unstructured":"World Health Organization.Transmission of SARS\u2013CoV\u20102: implications for infection prevention precautions.2020. 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