{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:58Z","timestamp":1791820918087,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR072577"],"award-info":[{"award-number":["P30 AR072577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL127118"],"award-info":[{"award-number":["R01 HL127118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AR007530"],"award-info":[{"award-number":["T32 AR007530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In rheumatoid arthritis (RA), there are limited data on risk factors for the clinical heart failure (HF) subtypes of HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). This study examined the association between inflammation and incident HF subtypes in RA. Because inflammation changes over time with disease activity, we hypothesized that the effect of inflammation may be stronger at the 5\u2010year follow\u2010up than at the standard 10\u2010year follow\u2010up from general population studies of cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied an electronic health record (EHR)\u2013based RA cohort with data pre\u2010 and post\u2010RA incidence. We applied a validated approach to identify HF and extract ejection fraction to classify HFrEF and HFpEF. Follow\u2010up started from the RA incidence date (index date) to the earliest occurrence of incident HF, death, last EHR encounter, or 10\u2009years. Baseline inflammation was assessed using erythrocyte sedimentation rate or C\u2010reactive protein values. Covariates included demographic characteristics, established HF risk factors, and RA\u2010related factors. We tested the association between baseline inflammation with incident HF and its subtypes using Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 9,087 patients with RA; 8.2% developed HF during 10\u2009years of follow\u2010up. Elevated inflammation was associated with increased risk for HF at both 5\u2010 and 10\u2010year follow\u2010ups (hazard ratio [HR] 1.66, 95% confidence interval [95% CI] 1.12\u20132.46 and HR 1.46, 95% CI 1.13\u20131.90, respectively), which is also seen for HFpEF at 5\u2009years (HR 1.72, 95% CI 1.09\u20132.70) and 10\u2009years (HR 1.45, 95% CI 1.07\u20131.94). HFrEF was not associated with inflammation for either follow\u2010up time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated inflammation early in RA diagnosis was associated with HF; this association was driven by HFpEF and not HFrEF, suggesting a window of opportunity for prevention of HFpEF in RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24804","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T01:26:36Z","timestamp":1633829196000},"page":"1036-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-4734","authenticated-orcid":false,"given":"Sicong","family":"Huang","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-7460","authenticated-orcid":false,"given":"Tianrun","family":"Cai","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2091","authenticated-orcid":false,"given":"Brittany N.","family":"Weber","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeling","family":"He","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar P.","family":"Dahal","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Veterans Administration Boston Healthcare System, West Roxbury, Massachusetts, and Harvard Medical School and Harvard T. H. Chan School of Public Health  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Hou","sequence":"additional","affiliation":[{"name":"Veterans Administration Boston Healthcare System, West Roxbury, Massachusetts Harvard T. H. Chan School of Public Health  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thany","family":"Seyok","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cagan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Mass General Brigham  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"DiCarli","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Joseph","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-3579","authenticated-orcid":false,"given":"Seoyoung C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-5428","authenticated-orcid":false,"given":"Daniel H.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Veterans Administration Boston Healthcare System  West Roxbury Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Cai","sequence":"additional","affiliation":[{"name":"Veterans Administration Boston Healthcare System, West Roxbury, Massachusetts, and Harvard Medical School and Harvard T. 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