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This study analyzed clinical, demographic, and socioeconomic factors that predict M\u2010HAQ scores over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 388 patients with baseline M\u2010HAQ scores from the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) early disease cohort with a mean disease duration of 2.5\u2009years, mean follow\u2010up time of 3.9\u2009years, and median follow\u2010up of 7.2\u2009years. A total of 1,950 M\u2010HAQ measurements were analyzed. Baseline disease characteristics were recorded, and the association of these characteristics with the M\u2010HAQ score was analyzed at baseline and longitudinally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower income and education levels, older age, and more severe skin involvement at enrollment were independent predictors of worse perceived functional disability over time (i.e., higher longitudinal M\u2010HAQ levels). Higher longitudinal modified Rodnan skin scores correlated with higher M\u2010HAQ scores, whereas higher longitudinal forced vital capacity percentage predicted values correlated with lower M\u2010HAQ scores over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for both univariable and multivariable analyses). Moreover, higher baseline M\u2010HAQ scores predicted higher mortality (hazard ratio 1.29, 95% confidence interval 1.09\u20131.52, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large, longitudinal study of early disease SSc demonstrates that severity of skin disease and socioeconomic factors such as educational level and income are important predictors of perceived functional disability in SSc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24812","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T09:35:09Z","timestamp":1636104909000},"page":"1066-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of Perceived Functional Status in Early Systemic Sclerosis: A Prospective Longitudinal Study of an Early Disease Cohort"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-7511","authenticated-orcid":false,"given":"Julia","family":"Chernis","sequence":"first","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Buni","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kazzaz","sequence":"additional","affiliation":[{"name":"The Methodist Hospital System  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ying","sequence":"additional","affiliation":[{"name":"Consultant  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marka","family":"Lyons","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-9978","authenticated-orcid":false,"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-2535","authenticated-orcid":false,"given":"Maureen","family":"Mayes","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1718","article-title":"Disease and symptom burden in systemic sclerosis: a patient perspective","volume":"34","author":"Suarez\u2010Almazor ME","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790040106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20620"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1790080312"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180093"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24734"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31829be125"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2016.01.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340405"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3846-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40557"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02329-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"}],"container-title":["Arthritis Care &amp; 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