{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:08:44Z","timestamp":1789420124380,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Medical Student Research Preceptorship"],"award-info":[{"award-number":["Medical Student Research Preceptorship"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["1\u2010KL\u20102\u2010TR\u2010002554"],"award-info":[{"award-number":["1\u2010KL\u20102\u2010TR\u2010002554"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Women with interstitial lung disease (ILD) are recommended to avoid pregnancy based on limited data. This study seeks to determine maternal and pregnancy outcomes in the largest\u2010to\u2010date cohort of patients with ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records in the Duke University Health System were reviewed for pregnancies in patients with a diagnosis of ILD with underlying autoimmune disease. Pregnancies were classified as having very severe, severe, mild\u2010moderate, or normal lung function based on pulmonary function tests (PFTs). Adverse pregnancy outcomes (APOs) were defined using the Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus and Antiphospholipid Syndrome APO (PROMISSE\u2010APO) and Severe PROMISSE\u2010APO criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 86 pregnancies in 60 women, 85% women were Black, 71% had sarcoidosis, and 29% had connective tissue disease (CTD)\u2013associated ILD (CTD\u2010ILD). Of the pregnancies with available PFTs (n\u2009=\u200959), 12% had very severe ILD, 25% had severe ILD, 51% had mild\u2010moderate ILD, and 12% had normal lung function.<\/jats:p>\n                    <jats:p>\n                      PROMISSE\u2010APOs occurred in 32% of pregnancies, including all pregnancies with very severe ILD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.02 across severity groups), 56% of pregnancies with CTD\u2010ILD, and 23% with sarcoidosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.02). Severe PROMISSE\u2010APOs occurred in 15% of pregnancies, including 60% with very severe ILD and 28% with CTD\u2010ILD. There were no maternal deaths. One woman required an intensive care hospital stay during pregnancy. Three women had volume overload after delivery that resolved with medical management. Seven women received oxygen during delivery, although none were intubated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although APOs were common in women with very severe ILD and underlying CTD, overall maternal morbidity and mortality were low. These data suggest women with ILD may be able to safely attempt pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.24814","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T08:55:56Z","timestamp":1636361756000},"page":"1166-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy Outcomes in Patients With Interstitial Lung Disease"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-3470","authenticated-orcid":false,"given":"Megan E. B.","family":"Clowse","sequence":"first","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-5562","authenticated-orcid":false,"given":"Aardra","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-5545","authenticated-orcid":false,"given":"Amanda","family":"Eudy","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Giattino","sequence":"additional","affiliation":[{"name":"Main Line Health System  Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra H.","family":"James","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh723"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171315"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91318-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0587"},{"issue":"58","key":"e_1_2_7_7_1","first-page":"3763","article-title":"Pregnancy course in patients with interstitial lung diseases [abstract]","volume":"44","author":"Novikova L","year":"2014","journal-title":"Eur Respir J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)01129-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1602243"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.4.837"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.11.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.04.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-3-6"},{"issue":"108","key":"e_1_2_7_15_1","first-page":"e1","article-title":"Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study","volume":"214","author":"Kim MY","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20864"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556743"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203321989803"}],"container-title":["Arthritis Care &amp; 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