{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:58:30Z","timestamp":1790251110525,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017759","name":"Childhood Arthritis and Rheumatology Research Alliance","doi-asserted-by":"publisher","award":["Small Grant Award"],"award-info":[{"award-number":["Small Grant Award"]}],"id":[{"id":"10.13039\/100017759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UL1TR002556"],"award-info":[{"award-number":["1UL1TR002556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the utility and acceptability for depression and anxiety screening of adolescents and young adults (AYA) with childhood\u2010onset systemic lupus erythematosus (cSLE) in the pediatric rheumatology setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AYA with cSLE, ages 12\u201321 years, from 8 collaborating sites, were consecutively screened for depression and anxiety with the Patient Health Questionnaire\u20109 (PHQ\u20109) and Generalized Anxiety Disorder 7\u2010item scale (GAD\u20107). Demographic and disease characteristics were collected, as well as patient\u2010reported outcome measures using the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric profile\u201025. Acceptability of screening was assessed with postscreening surveys completed by AYA and parents. Chi\u2010square and Wilcoxon rank sum tests examined the relationship between patient characteristics and history of previous screening. Spearman correlations examined relationships between screening scores, PROMIS domains, and other disease factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 106 AYA screened, 64 (60%) had been previously screened, 25 (24%) by general pediatricians. Thirty\u2010two (30%) AYA screened positive, including 24% for depression, 17% for anxiety, and 14% for suicidal ideation. Depression and anxiety symptom severity were highly correlated with increased PROMIS domain scores for fatigue and pain interference and moderately correlated with increased pain severity, decreased mobility, and decreased peer relationships. Eighty\u2010six percent of AYA and 95% of parents expressed comfort with screening in the pediatric rheumatology setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression, anxiety, and suicidal ideation are common among AYA with cSLE, and symptoms are correlated with important patient\u2010reported outcomes. Mental health screening in the pediatric rheumatology setting was highly acceptable among AYA with cSLE and their parents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24825","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T02:21:17Z","timestamp":1637547677000},"page":"724-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Multicenter Study of Utility and Acceptability of Depression and Anxiety Screening in Adolescents and Young Adults With <scp>Childhood\u2010Onset<\/scp> Systemic Lupus"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-9377","authenticated-orcid":false,"given":"Tamar B.","family":"Rubinstein","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine and Children's Hospital at Montefiore  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Dionizovik\u2010Dimanovski","sequence":"additional","affiliation":[{"name":"Children's Hospital at Montefiore  Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2716-2491","authenticated-orcid":false,"given":"Alaina M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children's Hospital at Vanderbilt  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey","family":"Smith","sequence":"additional","affiliation":[{"name":"Children's Mercy\u2010Kansas City  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Faust","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Rutstein","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manda","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children's Hospital at Vanderbilt  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-4991","authenticated-orcid":false,"given":"Jordan T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Children's Mercy\u2010Kansas City  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia G.","family":"Harris","sequence":"additional","affiliation":[{"name":"Children's Mercy\u2010Kansas City  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Riley Children's Hospital at Indiana  Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-1375","authenticated-orcid":false,"given":"Melissa","family":"Tesher","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Onel","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Gabbay","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York, and Nathan Kline Institute for Psychiatric Research  Orangeburg New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E. 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