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Systemic inflammatory\/metabolic CVD risk factors collected were high\u2010sensitivity C\u2010reactive protein (hsCRP) level, high\u2010density lipoprotein, triglycerides, total cholesterol, body mass index (BMI), systolic blood pressure, and hemoglobin A1c. Smoking history was also collected. Respondents indicated doctor\u2010diagnosed OA in the knees, hips, and\/or hands and were characterized as yes\/no OA and single site\/multisite OA. Individuals with OA were age\u2010 and sex\u2010matched to non\u2010OA controls. Covariates were age, sex, education, income, physical activity, timed up and go test findings, and comorbidities. A latent CVD risk variable was derived in women and men; standardized scores were categorized as follows: lowest, mid\u2010low, mid\u2010high, and highest risk. Associations with OA were quantified using ordinal logistic regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6,098 respondents (3,049 with OA) had a median age of 63\u2009years, and 55.8% were women. One\u2010third of OA respondents were in the highest risk category versus one\u2010fifth of non\u2010OA respondents. Apart from BMI (the largest contributor in both sexes), hsCRP level (an inflammation marker) was predominant in women, and metabolic factors and smoking were predominant in men. Overall, OA was associated with worse CVD risk quartiles compared with non\u2010OA. OA was increasingly associated with worse CVD risk quartiles with increasing risk thresholds among women with multisite OA, but not men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings suggest unique CVD risks by sex\/multisite subgroups and point to a potentially important role for inflammation in OA over and above traditional CVD risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24826","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T02:37:03Z","timestamp":1637894223000},"page":"893-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiovascular Risk Profile and Osteoarthritis\u2014Considering Sex and Multisite Joint Involvement: A Canadian Longitudinal Study on Aging"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-0993","authenticated-orcid":false,"given":"Anthony V.","family":"Perruccio","sequence":"first","affiliation":[{"name":"Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Arthritis Community Research &amp; Evaluation Unit, Dalla Lana School of Public Health, University of Toronto, and University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatabdy","family":"Zahid","sequence":"additional","affiliation":[{"name":"Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, and Arthritis Community Research &amp; Evaluation Unit  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-8603","authenticated-orcid":false,"given":"Calvin","family":"Yip","sequence":"additional","affiliation":[{"name":"Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Arthritis Community Research &amp; Evaluation Unit, and Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9903-6200","authenticated-orcid":false,"given":"J. 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