{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:21:30Z","timestamp":1783653690465,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24 AR057827"],"award-info":[{"award-number":["K24 AR057827"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR072577"],"award-info":[{"award-number":["P30 AR072577"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["RO1 AR074290"],"award-info":[{"award-number":["RO1 AR074290"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of chronic and occasional opioid use and identify risk factors of opioid use among persons with knee osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Medicare Current Beneficiary Survey to select a knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> cohort. We obtained data on demographics characteristics, marital status, comorbidities, insurance, and prescription medication coverage from survey data and linked Medicare claims. We included all prescribed medication records classified as opioid under the First Databank therapeutic antiarthritics or analgesics categories. We stratified individuals with knee <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> into 3 opioid use groups: 1) nonusers (0 prescriptions\/year), 2) occasional users (1\u20135 prescriptions\/year), and 3) chronic users (6+ prescriptions\/year). We built multivariable logistic regression models using a generalized estimating equation to determine correlates of chronic opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3,549 Medicare beneficiaries with knee OA and a mean\u2009\u00b1\u2009SD age of 78\u2009\u00b1\u20097\u2009years, 68% were female, 9% were chronic users, and 21% used opioids occasionally. Multivariable analysis showed that non\u2010Hispanic ethnicity (odds ratio [OR] 4.8, 95% confidence interval [95% CI] 2.2\u201310.2), divorced status (vs. married; OR 2.3, 95% CI 1.5\u20133.5), Medicaid eligibility (OR 1.9, 95% CI 1.3\u20132.7), depression (OR 1.9, 95% CI 1.5\u20132.5), chronic obstructive pulmonary disease (OR 1.9, 95% CI 1.4\u20132.5), and inability to walk without assistive devices (vs. no difficulty walking; OR 2.4, 95% CI 1.5\u20133.7) were independently associated with chronic opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total of 9% of persons with knee OA use opioids chronically. Efforts to find nonopioid regimens for treating knee OA pain should be tailored to patients at high risk for chronic use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24844","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T11:48:44Z","timestamp":1639741724000},"page":"876-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Opioid Use Among Medicare Beneficiaries With Knee Osteoarthritis: Prevalence and Correlates of Chronic Use"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-0892","authenticated-orcid":false,"given":"Elena","family":"Losina","sequence":"first","affiliation":[{"name":"Orthopaedic and Arthritis Center for Outcomes Research and Policy and Innovation eValuation in Orthopaedic Treatments Center, Brigham and Women's Hospital, Harvard Medical School and Boston University School of Public Health  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Song","sequence":"additional","affiliation":[{"name":"Orthopaedic and Arthritis Center for Outcomes Research and Policy and Innovation eValuation in Orthopaedic Treatments Center, Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-1465","authenticated-orcid":false,"given":"Gordon P.","family":"Bensen","sequence":"additional","affiliation":[{"name":"Orthopaedic and Arthritis Center for Outcomes Research and Policy and Innovation eValuation in Orthopaedic Treatments Center, Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-4670","authenticated-orcid":false,"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Orthopaedic and Arthritis Center for Outcomes Research and Policy and Innovation eValuation in Orthopaedic Treatments Center, Brigham and Women's Hospital, Harvard Medical School and Harvard T. 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