{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:26:11Z","timestamp":1772234771905,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore sustainability of achieved remission off medication and defined International League of Associations for Rheumatology (ILAR) categories in juvenile idiopathic arthritis (JIA) and describe the trajectory of disease course over time by comparing treatment, disease activity, and ILAR categories from baseline, 8\u2009years, and 18\u2009years after disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 373 of the 510 included patients were initially recruited consecutive cases of JIA from the prospective, longitudinal, population\u2010based Nordic JIA cohort with disease onset during 1997\u20132000 from Denmark, Norway, Sweden, and Finland in an 18\u2010year follow\u2010up study. Clinical data were collected consecutively at baseline, 8\u2009years, and 18\u2009years after disease onset and were evaluated regarding treatment, disease activity, and ILAR category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly more patients (70%) were off medication after 18\u2009years of follow\u2010up compared to after 8\u2009years (59.7%); nevertheless, the number of patients in remission had not increased (52% off medication versus 51% on medication). Twelve percent of patients changed ILAR category between 8\u2009years and 18\u2009years after disease onset. Almost half of the changes were due to updated information about heredity in a first\u2010degree relative. In the same period, the psoriatic arthritis group increased significantly in number (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), in contrast to the oligoarticular category, which decreased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). The undifferentiated group increased 24% from 8 to 18\u2009years of follow\u2010up; however, this increase was not significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this Nordic JIA cohort study, the remission rate did not increase even though significantly more patients were off medication at the 18\u2010year follow\u2010up compared to at the 8\u2010year follow\u2010up after disease onset. The distribution of patients in the ILAR categories continued to change significantly throughout the 18\u2010year study period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24857","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T09:43:38Z","timestamp":1641807818000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changing Patterns in Treatment, Remission Status, and Categories in a <scp>Long\u2010Term<\/scp> Nordic Cohort Study of Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-9908","authenticated-orcid":false,"given":"Mia","family":"Glerup","sequence":"first","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-5198","authenticated-orcid":false,"given":"Ellen D.","family":"Arnstad","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology, Trondheim, Norway, and Levanger Hospital, Nord\u2010Tr\u00f8ndelag Hospital Trust  Levanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-305X","authenticated-orcid":false,"given":"Veronika","family":"Rypdal","sequence":"additional","affiliation":[{"name":"University Hospital of North Norway and UiT The Artic University of Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Aalto","sequence":"additional","affiliation":[{"name":"University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marite","family":"Rygg","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology and St. Olavs Hospital Trondheim University  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Fasth","sequence":"additional","affiliation":[{"name":"Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillemor","family":"Berntson","sequence":"additional","affiliation":[{"name":"Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Nordal","sequence":"additional","affiliation":[{"name":"University Hospital of North Norway and UiT The Artic University of Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Nordic Study Group of Pediatric Rheumatology (NoSPeR)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_1","first-page":"1566","article-title":"Proposal for the development of classification criteria for idiopathic arthritides of 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