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Incident CVD events (coronary artery disease [CAD], stroke, heart failure [HF] hospitalization, venous thromboembolism, CVD\u2010related deaths) were identified using administrative data and the National Death Index. Covariates were derived from medical record, biorepository, and registry databases. Multivariable Cox models were generated to quantify associations between adipokine concentrations and CVD incidence. Five\u2010year incidence rates were predicted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2,598 participants, 639 (25%) had at least 1 CVD event over 19,585 patient\u2010years of follow\u2010up. High adiponectin levels were independently associated with HF hospitalization (hazard ratio [HR] 1.39 [95% confidence interval (95% CI) 1.07\u20131.79],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) and CVD\u2010related death (HR 1.49 [95% CI 1.16\u20131.92],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002) but not with other CVD events. High leptin was independently associated with CVD\u2010related death (HR 1.44 [95% CI 1.05\u20131.97],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). High FGF\u201021 levels were independently associated with lower rates of CAD (HR 0.75 [95% CI 0.58\u20130.97],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). In subgroup analyses, associations between high adiponectin and leptin levels with CVD\u2010related death were driven by strong associations in nonobese patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adipokines are associated with HF hospitalization and CVD\u2010related death in patients with RA, with stronger associations in nonobese participants. These findings suggest that adipokines effectively predict clinically important outcomes in RA perhaps through an association with body composition and metabolic health. Further study is needed to determine whether adipokine measures might augment existing tools to identify RA patients at increased risk of CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.24885","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T13:05:37Z","timestamp":1647867937000},"page":"768-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-9581","authenticated-orcid":false,"given":"Lydia E.","family":"Federico","sequence":"first","affiliation":[{"name":"University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-4157","authenticated-orcid":false,"given":"Tate M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-7649","authenticated-orcid":false,"given":"Katherine D.","family":"Wysham","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Healthcare System and University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0398-2308","authenticated-orcid":false,"given":"Michael D.","family":"George","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-3051","authenticated-orcid":false,"given":"Brian","family":"Sauer","sequence":"additional","affiliation":[{"name":"University of Utah Medical Center and Veterans Affairs Salt Lake City Health Care System  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartlett C.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Hunter","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center  Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2272","authenticated-orcid":false,"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Veterans Affairs Nebraska\u2013Western Iowa Health Care System and University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"University of Pennsylvania and Corporal Michael J. 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