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Our objective was to characterize the adverse event profile of CID patients following SARS\u2013CoV\u20102 vaccination and understand the relationship between reactogenicity and immunogenicity of SARS\u2013CoV\u20102 vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CID patients and healthy controls eligible to receive messenger RNA (mRNA) SARS\u2013CoV\u20102 vaccines participated in 3 study visits (pre\u2010vaccine, after dose 1, and after dose 2) in which blood and clinical data were collected. Assessment of adverse events were solicited within 7\u2009days of receiving each dose. Serum anti\u2013SARS\u2013CoV\u20102 spike IgG\u2009\u00b1\u2009antibody titers were quantified following vaccination. Statistical analysis was performed utilizing mixed models and tobit regressions, with adjustment for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present study included 441 participants (322 CID patients and 119 control subjects). Compared to controls, CID patients reported greater symptom severity after dose 1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), including more myalgia and fatigue (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). For immunogenicity, a higher symptom severity after dose 1 and a higher number of symptoms after dose 2 was associated with higher antibody titers (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05). Each increase of 1 symptom was associated with a 15.1% increase in antibody titer. Symptom association was strongest with site pain after dose 1 (105%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and fatigue after dose 2 (113%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CID have a distinct reactogenicity profile following SARS\u2013CoV\u20102 vaccination compared to controls. Furthermore, there is an association between increased reactogenicity and increased vaccine response. This finding may speak to the more variable immunogenicity in CID patients and may be an important indicator of vaccine response to the novel SARS\u2013CoV\u20102 vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24894","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:24:48Z","timestamp":1649751888000},"page":"1953-1960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reactogenicity of the Messenger <scp>RNA SARS<\/scp>\u2013<scp>CoV<\/scp>\u20102 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-3648","authenticated-orcid":false,"given":"Monica M.","family":"Yang","sequence":"first","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Paez","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Carividi","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Demissie","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niti","family":"Pawar","sequence":"additional","affiliation":[{"name":"University of California  San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia A.","family":"El\u2010Qunni","sequence":"additional","affiliation":[{"name":"Washington University School 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