{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:26:30Z","timestamp":1789514790024,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008641","name":"Center for Clinical and Translational Science, University of Cincinnati","doi-asserted-by":"publisher","award":["2KL2TR001426\u201005A"],"award-info":[{"award-number":["2KL2TR001426\u201005A"]}],"id":[{"id":"10.13039\/100008641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008641","name":"Center for Clinical and Translational Science, University of Cincinnati","doi-asserted-by":"publisher","award":["2UL1TR001425\u201005A1"],"award-info":[{"award-number":["2UL1TR001425\u201005A1"]}],"id":[{"id":"10.13039\/100008641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Systemic juvenile idiopathic arthritis (JIA) associated with lung disease (JIA\u2010LD) is a potentially life threating complication in children with systemic JIA. Although high\u2010resolution computed tomography (HRCT) is considered the gold standard imaging modality for evaluating interstitial lung disease (ILD), lung ultrasound (US) has shown utility for ILD screening in adults with connective tissue diseases at lower cost and without using ionizing radiation. The goals of this pilot study were to describe lung US features in children with known systemic JIA\u2010LD and to assess the feasibility of lung US in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children age\u2009&lt;18\u2009years with systemic JIA\u2010LD and healthy controls were enrolled. Lung US acquisition was performed at 14 lung positions. Demographic, clinical, and HRCT data were collected and reviewed. Feasibility was assessed through patient surveys. Lung US findings were qualitatively and semiquantitatively assessed and compared to HRCT findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lung US was performed in 9 children with systemic JIA\u2010LD and 6 healthy controls and took 12 minutes on average to perform. Lung US findings in systemic JIA\u2010LD included focal to diffuse pleural irregularity, granularity, and thickening, with associated scattered or coalesced B\u2010lines, and subpleural consolidations. Lung US findings appeared to correspond to HRCT findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lung US in systemic JIA\u2010LD reveals highly conspicuous abnormalities in the pleura and subpleura that appear to correlate with peripheral lung findings on HRCT. Lung US is a feasible imaging tool in children even from an early age. This study suggests a potential role of lung US in systemic JIA\u2010LD screening, diagnosis, and\/or prognostication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24957","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:28:22Z","timestamp":1653312502000},"page":"983-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lung Ultrasound in Children With Systemic Juvenile Idiopathic Arthritis\u2013Associated Interstitial Lung Disease"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7256","authenticated-orcid":false,"given":"Patricia","family":"Vega\u2010Fernandez","sequence":"first","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy V.","family":"Ting","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-6272","authenticated-orcid":false,"given":"Diane A.","family":"Mar","sequence":"additional","affiliation":[{"name":"Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Schapiro","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariani D.","family":"Deluna","sequence":"additional","affiliation":[{"name":"Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-3229","authenticated-orcid":false,"given":"Vivian E.","family":"Saper","sequence":"additional","affiliation":[{"name":"Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei A.","family":"Grom","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-7051","authenticated-orcid":false,"given":"Grant S.","family":"Schulert","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.06.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41073"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972310393758"},{"issue":"114","key":"e_1_2_7_6_1","first-page":"165","article-title":"The use of ultrasound for assessing interstitial lung involvement in connective tissue diseases","volume":"36","author":"Ferro F","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_7_1","first-page":"11","article-title":"Diagnostic accuracy of lung ultrasound for interstitial lung disease in patients with connective tissue diseases: a meta\u2010analysis","volume":"4","author":"Song G","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24338"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3446"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"834","article-title":"Definition and standardization of interstitial lung disease assessment by ultrasound: results from a Delphi process and web\u2010reliability exercise by the OMERACT Ultrasound Working Group (WG)","volume":"78","author":"Delle Sedie A","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2075-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21889"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-020-00444-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S156615"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2009.28.2.163"}],"container-title":["Arthritis Care &amp; 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