{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:59:36Z","timestamp":1787759976199,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence and impact on damage accrual of different levels of disease activity in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with GPA and MPA followed for \u22655\u2009years in 2 different centers were included. Disease activity and damage were assessed using the Birmingham Vasculitis Activity Score (BVAS) and Vasculitis Damage Index (VDI), respectively. Three levels of remission were defined: complete remission (BVAS\u2009=\u20090, negative for antineutrophil cytoplasmic antibody [ANCA], off treatment), clinical remission off therapy (CROffT; BVAS\u2009=\u20090, positive for ANCA), and clinical remission on therapy (CROnT; BVAS\u2009=\u20090, negative or positive for ANCA, glucocorticoids \u22645 mg\/day and\/or immunosuppressant). A low disease activity state (LDAS) was defined as 0\u2009&lt; BVAS \u22643, low\u2010dose glucocorticoids (\u22647.5 mg\/day), and\/or immunosuppressant. Remission or LDAS were defined as prolonged when lasting \u22652 consecutive years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 167 patients were included: 128 (76.6%) with GPA, 39 (23.4%) with MPA, mean\u2009\u00b1\u2009SD age 51.0\u2009\u00b1\u200916.7\u2009years. During a 5\u2010year follow\u2010up, 10 patients (6.0%) achieved prolonged complete remission, 6 (3.6%) prolonged CROffT, 89 (53.3%) prolonged CROnT, 42 (25.1%) prolonged LDAS, and 20 (12.0%) never achieved LDAS. The VDI score at 5\u2009years progressively worsened according to increasing levels of disease activity targets (complete remission, CROffT, CROnT, and LDAS). The mean\u2009\u00b1\u2009SD 5\u2010year VDI score was higher in patients not achieving prolonged remission compared to those who did (3.7\u2009\u00b1\u20092.0 versus 2.2\u2009\u00b1\u20091.9; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). By multivariate analysis, baseline ear, nose, and throat (<jats:italic>P<\/jats:italic>\u2009=\u20090.006), and lung involvement (<jats:italic>P<\/jats:italic>\u2009=\u20090.047) were negative predictors of prolonged remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than 60% of patients with GPA\/MPA achieved prolonged remission, which was associated with better long\u2010term outcomes. In contrast, prolonged LDAS correlated with increased damage accrual and was not a sufficient treatment target.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24958","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:29:33Z","timestamp":1653312573000},"page":"1158-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Remission and Low Disease Activity in Granulomatosis With Polyangiitis and Microscopic Polyangiitis: Prevalence and Impact on Damage Accrual"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-8236","authenticated-orcid":false,"given":"Paolo","family":"Delvino","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo Foundation, University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sardanelli","sequence":"additional","affiliation":[{"name":"Ospedale Civile Sant'Andrea  La Spezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-6772","authenticated-orcid":false,"given":"Sara","family":"Monti","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo Foundation, University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cohen","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-9203","authenticated-orcid":false,"given":"Xavier","family":"Pu\u00e9chal","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlomaurizio","family":"Montecucco","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. 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