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This systematic review aims to evaluate the effects of disease\u2010modifying antirheumatic drugs (DMARDs) on the patient\u2010relevant domains of pain, fatigue, activity limitation, overall emotional and physical health impact, and work\/school\/housework ability and productivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted to identify randomized controlled trials wherein registered DMARDs were compared with placebo or methotrexate and reported the effects on patient\u2010reported outcomes included in the International Consortium of Health Outcomes Measurement standard set for inflammatory arthritis. Random effects meta\u2010analyses using the standardized mean differences of change scores as the effect measure were performed for the domains of pain, fatigue, and activity limitation, comparing DMARDs with placebo and methotrexate. The other 2 domains were presented narratively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across the 5 domains, 69 records belonging to 52 studies were identified. All meta\u2010analyses showed a decrease of burden when DMARDs were compared with placebo (standardized mean differences [95% confidence interval] in pain \u22120.80 [\u22120.99, \u22120.61], fatigue \u22120.48 [\u22120.64, \u22120.32], and activity limitation \u22120.56 [\u2212 0.63, \u22120.49]) and when compared with methotrexate (\u22120.55 [\u22120.70, \u22120.41), \u22120.44 [\u22120.55, \u22120.33], and\u2009\u2212\u20090.37 [\u22120.44, \u22120.30], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DMARDs decrease the burden in all the domains that are relevant to patients. Effect sizes may be influenced by DMARD type. Therefore, in the decision for rheumatoid arthritis treatment, patient\u2010reported outcomes should be taken into account.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24965","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T11:29:35Z","timestamp":1654255775000},"page":"1659-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Meta\u2010Analyses on the Effects of Disease\u2010Modifying Antirheumatic Drugs on the Most Relevant Patient\u2010Reported Outcome Domains in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-219X","authenticated-orcid":false,"given":"Marijke","family":"van den Dikkenberg","sequence":"first","affiliation":[{"name":"Maasstad Hospital and Erasmus School of Health Policy and Management  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-5530","authenticated-orcid":false,"given":"Nathalie","family":"Luurssen\u2010Masurel","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjallingius Martijn","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Maasstad Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-6926","authenticated-orcid":false,"given":"Marc\u2010Redwart","family":"Kok","sequence":"additional","affiliation":[{"name":"Maasstad Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Maria Wilhelmina","family":"Hazes","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal Hendrik Pieter","family":"de Jong","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirisa","family":"Lopes\u2010Barreto","sequence":"additional","affiliation":[{"name":"Maasstad Hospital and Erasmus School of Health Policy and Management  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique Elisabeth Adriana Maria","family":"Weel\u2010Koenders","sequence":"additional","affiliation":[{"name":"Maasstad Hospital and Erasmus School of Health Policy and Management  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001220"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204798"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa845"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4491"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab631"},{"key":"e_1_2_7_9_1","article-title":"Patient and clinical relevant outcomes in rheumatoid arthritis; 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