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A total of 415 people with knee osteoarthritis ages 45\u201380\u2009years and body mass index of 28\u201340 kg\/m<jats:sup>2<\/jats:sup> were assigned to 1 of 2 telehealth\u2010delivered exercise programs, 1 without (n\u00a0=\u00a0172) and 1 with (n\u00a0=\u00a0175) a dietary component (ketogenic very low calorie diet), or to an education control (n\u00a0=\u00a067), for 6 months, with 6 months follow\u2010up. The primary economic outcomes were quality\u2010adjusted life years (QALYs) and health system costs. Measured costs were the direct intervention (consultations, equipment\/resources, and meal replacements) and health care use in 2020 Australian dollars ($AU1.5\u00a0=\u00a0$US1). Secondary analysis included weight loss and work productivity gains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical trial demonstrated greater improvements in pain and function compared to information only for individuals with knee osteoarthritis and overweight\/obesity. We can be 88% confident that diet plus exercise is cost effective ($45,500 per QALY), 53% confident that exercise is cost\u2010effective ($67,600 per QALY) compared to the control, and 86% confident that augmenting exercise with the diet program is cost effective ($21,100 per QALY).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Telehealth\u2010delivered programs targeting exercise with dietary intervention for people with knee osteoarthritis who have overweight\/obesity are likely to be cost\u2010effective, particularly if potential long\u2010term gains from weight loss and work productivity are realized.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25022","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T09:30:36Z","timestamp":1663234236000},"page":"1311-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cost\u2010Effectiveness of Telehealth\u2010Delivered Exercise and Dietary Weight Loss Programs for Knee Osteoarthritis Within a Twelve\u2010Month Randomized Trial"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-3320","authenticated-orcid":false,"given":"Anthony","family":"Harris","sequence":"first","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana S.","family":"Hinman","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-6058","authenticated-orcid":false,"given":"Belinda J.","family":"Lawford","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorlene","family":"Egerton","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Keating","sequence":"additional","affiliation":[{"name":"Medibank Private  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Brown","sequence":"additional","affiliation":[{"name":"Medibank Private  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Metcalf","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Spiers","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Sumithran","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Quicke","sequence":"additional","affiliation":[{"name":"Keele University  Keele UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L.","family":"Bennell","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Australian Institute of Health and Welfare.Osteoarthritis.2020. 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