{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:47:03Z","timestamp":1781304423929,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR002558"],"award-info":[{"award-number":["KL2 TR002558"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003017"],"award-info":[{"award-number":["UL1TR003017"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K23 AR068441"],"award-info":[{"award-number":["K23 AR068441"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether hydroxychloroquine (HCQ) dose is associated with adverse cardiac outcomes in patients with systemic lupus erythematosus (SLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SLE taking HCQ and with \u22651 echocardiogram followed at a tertiary care center in the Bronx, New York between 2005 and 2021 were included. The HCQ weight\u2010based dose at the HCQ start date was the main exposure of interest. The outcome was incident all\u2010cause heart failure with reduced ejection fraction (HFrEF), life\u2010threatening arrhythmia, or cardiac death. We used Fine\u2010Gray regression models with death as a competing event to study the association of HCQ dose with the outcome. Due to a significant interaction between smoking and HCQ exposure, models were stratified by smoking status. Propensity score analysis was performed as a secondary analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 294 patients, 37 (13%) developed the outcome over a median follow\u2010up time of 7.9\u2009years (interquartile range [IQR] 4.2\u201312.3\u2009years). In nonsmokers (n\u00a0=\u00a0226), multivariable analysis adjusted for age, body mass index, hypertension, chronic kidney disease, diabetes mellitus, and thromboembolism showed that higher HCQ weight\u2010based doses were not associated with an increased risk of the outcome (subdistribution hazard ratio [HR] 0.62 [IQR 0.41\u20130.92], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Similarly, higher baseline HCQ doses were not associated with a higher risk of the outcome among smokers (n\u00a0=\u00a068) (subdistribution HR 0.85 [IQR 0.53\u20131.34] per mg\/kg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.48). Propensity score analysis showed comparable results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher HCQ doses were not associated with an increased risk of HFrEF, life\u2010threatening arrhythmia, or cardiac death among patients with SLE and may decrease the risk among nonsmokers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25052","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:45:26Z","timestamp":1667547926000},"page":"1673-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Hydroxychloroquine Dose With Adverse Cardiac Events in Patients With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-5283","authenticated-orcid":false,"given":"Alejandra Londono","family":"Jimenez","sequence":"first","affiliation":[{"name":"McFarland Clinic  Ames 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Salgado","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine\/Jacobi Medical Center  the Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu B.","family":"Mowrey","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine\/Montefiore Medical Center  the Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-1339","authenticated-orcid":false,"given":"Daniel B.","family":"Horton","sequence":"additional","affiliation":[{"name":"Rutgers Center for Pharmacoepidemiology and Treatment Science and Institute for Health, Health Care Policy, and Aging Research  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Briceno","sequence":"additional","affiliation":[{"name":"UnityPoint Health  Des Moines Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-3057","authenticated-orcid":false,"given":"Anna","family":"Broder","sequence":"additional","affiliation":[{"name":"Hackensack University Hospital  Hackensack New 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