{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:33:46Z","timestamp":1793457226080,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007673","name":"Fondation Centre de Recherches M\u00e9dicales Carlos et Elsie de Reuter","doi-asserted-by":"publisher","award":["672\u20102022"],"award-info":[{"award-number":["672\u20102022"]}],"id":[{"id":"10.13039\/501100007673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess how and to what extent socioeconomic status and ethnicity\/race of participants are reported in randomized controlled trials (RCTs) on systemic sclerosis (SSc), and to estimate the representativeness of different ethnic\/racial groups in SSc RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched all published RCTs on SSc indexed in PubMed. We retrieved information on main features of RCTs published from 2000 onward and recorded for each study whether race\/ethnicity was reported; how ethnicity\/race was defined and assigned; and the number of patients included for each racial\/ethnic group. Multivariable logistic regression was used to identify factors associated with race\/ethnicity reporting. Proportion of races\/ethnicities included in US\u2010based RCTs on SSc was examined and compared with US demographic data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 106 studies, mostly conducted in Europe (42%) or North America (25%), published after 2010 (74%), and enrolling a total of 6,693 patients. About one\u2010third of studies provided information about race\/ethnicity, with no improved reporting over time. Only 2 papers reported patient's socioeconomic status. Study location (US or intercontinental) was the only significant factor associated with a better reporting of race\/ethnicity in multivariable analysis. In studies where race\/ethnicity was reported, White patients were mostly represented (79%), followed by Asian (7%), and African American (6%). In the sensitivity analysis limited to studies from the US, underrepresentation of African American patients was observed in the 2000\u20132010 time period, but not later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Documentation of race\/ethnicity and socioeconomic status is poor in RCTs on SSc. More effort should be made to document race\/ethnicity and socioeconomic status and to promote diversity in SSc RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25059","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:28:56Z","timestamp":1668126536000},"page":"1698-1705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reporting and Representativeness of Race, Ethnicity, and Socioeconomic Status in Systemic Sclerosis Randomized Trials: An Observational Study"],"prefix":"10.1002","volume":"75","author":[{"given":"Edouard","family":"Chaix","sequence":"first","affiliation":[{"name":"Geneva University Hospitals and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mongin","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Gabay","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-8806","authenticated-orcid":false,"given":"Michele","family":"Iudici","sequence":"additional","affiliation":[{"name":"Geneva University Hospitals and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118410868.wbehibs395"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2018.11.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb0803929"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05049-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.61"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24892"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2020.07.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180042"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390814"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez486"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/23971983221074749"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4291-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3846-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171443"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3475-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab437"},{"issue":"264","key":"e_1_2_6_19_1","first-page":"W64","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses: the PRISMA statement","volume":"151","author":"Moher D","year":"2009","journal-title":"Ann Intern Med"},{"key":"e_1_2_6_20_1","first-page":"130","article-title":"How to identify randomized controlled trials in MEDLINE: ten years on","volume":"94","author":"Glanville JM","year":"2006","journal-title":"J Med Libr Assoc"},{"key":"e_1_2_6_21_1","unstructured":"Clarivate. 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