{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:00:42Z","timestamp":1794013242238,"version":"4.8.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008641","name":"Center for Clinical and Translational Science, University of Cincinnati","doi-asserted-by":"publisher","award":["2UL1TR001425\u201005A1"],"award-info":[{"award-number":["2UL1TR001425\u201005A1"]}],"id":[{"id":"10.13039\/100008641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017759","name":"Childhood Arthritis and Rheumatology Research Alliance","doi-asserted-by":"publisher","award":["Arthritis Foundation Small Grant"],"award-info":[{"award-number":["Arthritis Foundation Small Grant"]}],"id":[{"id":"10.13039\/100017759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2KL2TR001426\u201005A1"],"award-info":[{"award-number":["2KL2TR001426\u201005A1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30AR076316"],"award-info":[{"award-number":["P30AR076316"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the frequency of subclinical synovitis on musculoskeletal ultrasonography (MSUS) in juvenile idiopathic arthritis (JIA) and correlate patient\u2010 and provider\u2010reported outcome measures with MSUS synovitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>JIA patients with an active joint count (AJC) of &gt;4 underwent a 42\u2010joint MSUS performed at baseline and 3 months. B\u2010mode and power Doppler images were obtained and scored (range 0\u20133) for each of the 42 joints. Outcomes evaluated included physician global assessment of disease activity (PhGA), patient global assessment of disease activity (PtGA), patient pain, Childhood Health Assessment Questionnaire (C\u2010HAQ), and AJC. Subclinical synovitis was defined as synovitis detected by MSUS only. Generalized estimation equations were used to test the relationship between clinical arthritis (positive\/negative) and subclinical synovitis (positive\/negative). Spearman's correlation coefficients (r<jats:sub>s<\/jats:sub>) were calculated to determine the association between MSUS synovitis and patient\u2010 and physician\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 30 patients, subclinical synovitis was detected in 30% of joints. Clinical arthritis of the fingers, wrists, and knee joints was significantly associated with MSUS synovitis in these joints. PtGA and the C\u2010HAQ had a moderate (r<jats:sub>s<\/jats:sub>\u00a0=\u00a00.44, <jats:italic>P<\/jats:italic>\u00a0=\u20090.014) to weak (r<jats:sub>s<\/jats:sub>\u00a0=\u00a00.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) correlation with MSUS synovitis. There was a statistically significant strong correlation between MSUS synovitis and PhGA (r<jats:sub>s<\/jats:sub>\u00a0=\u00a00.61, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), but a weak correlation with AJC (r<jats:sub>s<\/jats:sub>\u00a0=\u00a00.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) at the follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subclinical synovitis was commonly observed in this cohort of JIA patients. The fair\u2010to\u2010moderate correlation of MSUS synovitis with patient\u2010 and provider\u2010reported outcomes suggests that MSUS assesses a different, possibly more objective, domain not determined by traditional JIA outcome measurements.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25073","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T02:20:18Z","timestamp":1671416418000},"page":"1815-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Musculoskeletal Ultrasound and the Assessment of Disease Activity in Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-7256","authenticated-orcid":false,"given":"Patricia","family":"Vega\u2010Fernandez","sequence":"first","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-9340","authenticated-orcid":false,"given":"Edward J.","family":"Oberle","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Henrickson","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Huggins","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-1756","authenticated-orcid":false,"given":"Sampath","family":"Prahalad","sequence":"additional","affiliation":[{"name":"Emory University and Children's Hospital of Atlanta  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Cassedy","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Roth","sequence":"additional","affiliation":[{"name":"Children's Hospital Eastern Ontario  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy V.","family":"Ting","sequence":"additional","affiliation":[{"name":"University of Cincinnati and Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Childhood Arthritis and Rheumatology Research Alliance Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.004"},{"issue":"85","key":"e_1_2_8_3_1","article-title":"Joint counts in inflammatory arthritis","volume":"32","author":"Scott IC","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22461"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24823"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23130"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0240-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24759"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0085-5"},{"key":"e_1_2_8_10_1","first-page":"69","article-title":"Statistics corner: a guide to appropriate use of correlation coefficient in medical research","volume":"24","author":"Mukaka MM","year":"2012","journal-title":"Malawi Med J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211696"},{"key":"e_1_2_8_12_1","first-page":"329","article-title":"Ultrasound changes in synovial abnormalities induced by treatment in juvenile idiopathic arthritis","volume":"36","author":"Lanni S","year":"2018","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"e_1_2_8_13_1","article-title":"Musculoskeletal ultrasound study in childhood arthritis: a limited examination [abstract]. 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