{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:44:33Z","timestamp":1776095073993,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001009","name":"BMSF","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the frequency and trajectories of individual patients with polyarticular\u2010course juvenile idiopathic arthritis (JIA) achieving novel composite end points on abatacept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a clinical trial of subcutaneous abatacept (NCT01844518) and a post hoc analysis of intravenous abatacept (NCT00095173) in patients with polyarticular\u2010course JIA were included. Three end points were defined and evaluated: combined occurrence of low disease activity (LDA) measured by the Juvenile Arthritis Disease Activity Score; 50% improvement in American College of Rheumatology criteria for JIA (ACR50); and patient\u2010reported outcomes. Patient\u2010reported outcomes included visual analog scale score of minimal pain (pain\u2010min) and Childhood Health Assessment Questionnaire disability index score of 0 (C\u2010HAQ DI0). In this post hoc analysis, maintenance of month 13 and 21 end points (LDA+pain\u2010min, LDA+C\u2010HAQ DI0, and ACR50+pain\u2010min) in those who achieved them at month 4 was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Composite end points (LDA+pain\u2010min, LDA+C\u2010HAQ DI0, and ACR50+pain\u2010min) were achieved at month 4 (44.7%, 19.6%, and 58.9% of the 219 patients treated with subcutaneous abatacept, respectively). Of those who achieved LDA+pain\u2010min at month 4, 84.7% (83 of 98) and 65.3% (64 of 98) maintained LDA+pain\u2010min at months 13 and 21, respectively. The proportions of patients meeting LDA+pain\u2010min outcomes increased from 44.7% (98 of 219) at month 4 to 54.8% (120 of 219) at month 21. The frequency of patients who met an LDA+C\u2010HAQ DI score of 0 increased from 19.6% (43 of 219) at month 4 to 28.8% (63 of 219) at month 21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among individual patients with polyarticular\u2010course JIA treated with abatacept who achieved 1 of the combined clinical and patient\u2010reported outcomes composite end points, many maintained them over 21 months of abatacept treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25156","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T22:48:36Z","timestamp":1684882116000},"page":"2259-2266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Long\u2010Term<\/scp> Maintenance of Clinical Responses by Individual Patients With <scp>Polyarticular\u2010Course<\/scp> Juvenile Idiopathic Arthritis Treated With Abatacept"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Tzaribachev","sequence":"additional","affiliation":[{"name":"PRI Research  Bad Bramstedt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Louw","sequence":"additional","affiliation":[{"name":"Panorama Medical Centre  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Calvo Penades","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico de La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Avila\u2010Zapata","sequence":"additional","affiliation":[{"name":"Hospital Star Medica Merida  Yucatan Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Horneff","sequence":"additional","affiliation":[{"name":"Asklepios Klinik, Sankt Augustin, Germany, and University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-5298","authenticated-orcid":false,"given":"Ivan","family":"Foeldvari","sequence":"additional","affiliation":[{"name":"Hamburger Zentrum f\u00fcr Kinder\u2010 und Jugendrheumatologie  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Kingsbury","sequence":"additional","affiliation":[{"name":"Randall Children's Hospital at Legacy Emanuel  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eliana","family":"Paz Gastanaga","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Anglo Americana  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Wouters","sequence":"additional","affiliation":[{"name":"Leuven University Hospital  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Breedt","sequence":"additional","affiliation":[{"name":"University of Pretoria  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Wong","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb  Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Askelson","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb  Braine\u2010L'Alleud Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb  Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-0130","authenticated-orcid":false,"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8407-7782","authenticated-orcid":false,"given":"Nicolino","family":"Ruperto","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini, UOSID Centro Trial  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23870"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60363-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40466"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60998-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39234"},{"issue":"2","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/annrheumdis-2019-eular.236","article-title":"OP0056 maintenance of clinical response in individual children with juvenile idiopathic arthritis treated with subcutaneous abatacept","volume":"78","author":"Ruperto N","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216843"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400703"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/237258"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200237"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080432"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.048"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131536"},{"issue":"23","key":"e_1_2_9_16_1","first-page":"S1","article-title":"Cross\u2010cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodology","volume":"4","author":"Ruperto N","year":"2001","journal-title":"Clin Exp Rheumatol"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:34:50Z","timestamp":1759415690000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.25156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,22]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/acr.25156"],"URL":"https:\/\/doi.org\/10.1002\/acr.25156","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,22]]},"assertion":[{"value":"2022-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}