{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:05:31Z","timestamp":1788584731739,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001844","name":"Scleroderma Foundation","doi-asserted-by":"publisher","award":["New Investigator Grant"],"award-info":[{"award-number":["New Investigator Grant"]}],"id":[{"id":"10.13039\/100001844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n Objective<\/jats:title>\n Despite efforts at early detection, patients with systemic sclerosis (SSc) pulmonary hypertension (PH) present with advanced disease. We sought to determine whether endothelial biomarkers (asymmetric dimethylarginine [ADMA], soluble endoglin [sEng], and pentraxin\u20103 [PTX\u20103]) can determine SSc\u2010PH risk or differentiate between SSc\u2010PH subgroups.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n ADMA, sEng, and PTX\u20103 were measured by enzyme\u2010linked immunosorbent assay in four groups: 1) 18 healthy controls, 2) 74 patients with SSc\u2010PH, 3) 44 patients at high risk for PH features, and 4) 10 patients with low risk for PH features. High\u2010risk features included a diffusion capacity (DL\n co<\/jats:sc>\n ) less than 55% with a forced vital capacity (FVC) greater than 70%, an FVC\/DL\n co<\/jats:sc>\n ratio of >1.6, or a right ventricular systolic pressure on an echocardiogram greater than or equal to 40\u2009mm Hg. ADMA, sEng, and PTX\u20103 were compared between these four groups as well as stratified based on the three SSc\u2010PH clinical classification groups (pulmonary arterial hypertension [PAH], left\u2010heart disease, and interstitial lung disease [ILD]).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PTX\u20103 was significantly lower in subjects with SSc at low risk for PH (median 27.0 pg\/ml [interquartile range (IQR) 19.0\u201347.3];\n P<\/jats:italic>\n <\u20090.003) than the other groups. The area under the receiver operating characteristic curve was 0.87 (95% confidence interval 0.76\u20130.98,\n P<\/jats:italic>\n =\u20090.0002) to differentiate low risk from high risk for patients with PH. PTX\u20103 was significantly lower in SSc\u2010PH from disease of the left side of the heart (57.5 pg\/ml [IQR 39.8\u201379.0];\n P<\/jats:italic>\n <\u20090.01) compared to SSc\u2010PH from either PAH (85.5 pg\/ml [IQR 56.3\u2013104.5]) or ILD (90.3 pg\/ml [IQR 74.9\u2013111.0]). Neither ADMA nor sEng differed between the four groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PTX\u20103 is a promising biomarker of PH risk status in patients with SSc as well as a possible marker of precapillary PH, which should be validated in an external cohort.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.25180","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:35:11Z","timestamp":1687826111000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Endothelial Biomarkers of Systemic\n Sclerosis\u2013Associated<\/scp>\n Pulmonary Hypertension"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-1801","authenticated-orcid":false,"given":"Matthew R.","family":"Lammi","sequence":"first","affiliation":[{"name":"Louisiana State University Health Sciences Center, University Medical Center\u2010New Orleans, and New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen D.","family":"Kolstad","sequence":"additional","affiliation":[{"name":"University of California Los Angeles Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley Ann","family":"Saketkoo","sequence":"additional","affiliation":[{"name":"University Medical Center\u2010New Orleans, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, and Tulane University School of Medicine New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avani","family":"Khatri","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Utz","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia D.","family":"Steen","sequence":"additional","affiliation":[{"name":"Georgetown University Medical Center Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine and Palo Alto VA Health Care System Palo Alto 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