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Their persistent symptoms are strikingly similar to those of fibromyalgia and myalgic encephalomyelitis\/chronic fatigue syndrome, including fatigue, post\u2010exertional malaise, myalgias\/arthralgias, and sleep and cognitive disturbances in 50% to 100% of cases.<\/jats:p><jats:p>Analogous pathophysiologic pathways in fibromyalgia (FM), myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS), and long COVID include host\u2013microbial interactions in the absence of direct tissue invasion and absence of systemic autoimmunity, with\u00a0evidence for immune dysregulation as well as autonomic, peripheral, and central nervous system dysfunction. Current treatment of long COVID has been based on multidisciplinary management recommended for FM and ME\/CFS and has been formalized and made widely available by funding for nationwide long COVID clinics. Long COVID and its treatment should be distinguished by the presence or absence of organ damage. The acknowledged role of patient engagement in research and open dialogue regarding work and disability noted in long COVID may have meaningful impact on patients with FM and ME\/CFS. Hopefully, advances in basic long COVID research will aid in understanding FM and ME\/CFS, and rheumatologists should thus be involved in such research and patient care.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25210-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/acr.25210","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T01:43:55Z","timestamp":1690854235000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Applying Lessons From Rheumatology to Better Understand Long <scp>COVID<\/scp>"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-0243","authenticated-orcid":false,"given":"Don L.","family":"Goldenberg","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine, Boston, Massachusetts, and Oregon Health Sciences University  Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2020.113426"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2109285"},{"key":"e_1_2_3_4_1","unstructured":"NICE Guideline 2020 National Institute for Health and Care Excellence Royal College of General Practitioners Scottish Intercollegiate Guidelines Network. 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