{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:34:01Z","timestamp":1774935241956,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871288"],"award-info":[{"award-number":["81871288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900636"],"award-info":[{"award-number":["81900636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess post\u2010COVID\u201019 vaccination gout flare risk with differing baseline flare burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively studied gout patients with infrequent or frequent flares, defined as \u22641 flare\/year or \u22652 flares\/year, respectively. COVID\u201019 vaccine\u2010naive patients managed with urate\u2010lowering therapy between February and June 2021 were included and voluntarily decided on vaccination. Participants were followed for 12\u2009weeks after enrollment or first vaccine dose. Gout flares and risk factors were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 530 participants, 308 (58.1%) had infrequent flares and 222 (41.9%) had frequent flares at baseline, with 248 (142 infrequent and 106 frequent) receiving two\u2010dose COVID\u201019 vaccination. Vaccination increased cumulative flare incidence at 12\u2009weeks in the infrequent but not the frequent flare group (26.1% vs 10.8%, <jats:italic>P<\/jats:italic> =\u20090.001, compared with 60.4% vs 65.5%, <jats:italic>P<\/jats:italic> =\u20090.428). Flare incidence in the final 4\u2009weeks of observation decreased significantly only in the vaccinated infrequent flare group (4.3% vs 12.0%, <jats:italic>P<\/jats:italic> =\u20090.017). Multivariable analyses showed that vaccination (odds ratio [OR] 2.82, 95% confidence interval [95% CI] 1.50\u20135.30, <jats:italic>P<\/jats:italic> =\u20090.001), flare in the preceding year (OR 1.95, 95% CI 1.03\u20133.71, <jats:italic>P<\/jats:italic> =\u20090.04), and body mass index (OR 1.09, 95% CI 1.01\u20131.19, <jats:italic>P<\/jats:italic> =\u20090.03) were independently associated with increased flare risk in the infrequent flare group. Baseline serum urate (mg\/dl) was an independent risk factor in the frequent flare group (OR 1.23, 95% CI 1.05\u20131.45, <jats:italic>P<\/jats:italic> =\u20090.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 vaccination was associated with increased early gout flares only in patients with previously infrequent flares.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25215-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25215","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T23:20:51Z","timestamp":1691536851000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>COVID<\/scp>\u201019 Vaccination and Gout Flare Risk in Patients With Infrequent or Frequent Flares: A Prospective Cohort Study"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5107-5323","authenticated-orcid":false,"given":"Yuwei","family":"He","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Qingdao University, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, and Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-0130","authenticated-orcid":false,"given":"Xiaomei","family":"Xue","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-7473","authenticated-orcid":false,"given":"Robert","family":"Terkeltaub","sequence":"additional","affiliation":[{"name":"VA San Diego Medical Center, San Diego, and University of California San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University and Shandong Provincial Clinical Research Center for Immune Diseases and Gout  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-1489","authenticated-orcid":false,"given":"Fei","family":"Yan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Pang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinde","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University and Shandong Provincial Clinical Research Center for Immune Diseases and Gout  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-0755","authenticated-orcid":false,"given":"Xuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-3731","authenticated-orcid":false,"given":"Changgui","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University, Shandong Provincial Clinical Research Center for Immune Diseases and Gout, and Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshu","family":"Sun","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University and Shandong Provincial Clinical Research Center for Immune Diseases and Gout  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Center for Systems Science and Engineering.COVID\u201019 dashboard. 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