{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:43:21Z","timestamp":1792590201350,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is limited literature describing the overlap of systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), and the studies have employed a range of case definitions. Our study used the new EULAR\/American College of Rheumatology (ACR) SLE classification criteria to define SSc\u2010SLE cases among our center's SSc cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center, retrospective study of a previously described cohort of patients with SSc. Patient data were re\u2010abstracted to evaluate for fulfillment of the 2019 EULAR\/ACR classification criteria for SLE. Demographic, laboratory, clinical features, and mortality were compared among patients with SSc\u2010SLE and patients with SSc alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 402 patients with SSc that were analyzed, 40 (10%) fulfilled the 2019 EULAR\/ACR SLE classification criteria. Neuropsychiatric and renal involvement were rare. An initial SLE diagnosis was purported in 43% of the patients with SSc\u2010SLE and 7% of patients with SSc alone (<jats:italic>P<\/jats:italic> &lt;\u20090.001). Patients with SSc\u2010SLE were more likely to be female, African American, and with limited cutaneous SSc. Anti\u2013U1\u2010RNP antibody positivity prevalence was 30% among patients with SSc\u2010SLE and 6.6% among patients with SSc alone (<jats:italic>P<\/jats:italic> &lt;\u20090.001). Death during follow\u2010up occurred in 12 patients (30%) with SSc\u2010SLE and in 81 patients (22%) with SSc alone, but there was no difference in survival among the groups per log rank test (<jats:italic>P<\/jats:italic> =\u20090.404).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ten percent of patients with SSc fulfill the 2019 EULAR\/ACR classification criteria for SLE. These patients comprise a distinct demographic, serologic, and clinical phenotype but have similar severe SSc\u2010specific end\u2010organ damage and mortality as patients with SSc alone. Patients with SLE with Raynaud phenomenon should be evaluated for SSc\u2010specific autoantibodies and scleroderma organ involvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25235","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T02:39:31Z","timestamp":1694399971000},"page":"311-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and Characteristics of Patients With Systemic Sclerosis Fulfilling the 2019 <scp>EULAR<\/scp>\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0949","authenticated-orcid":false,"given":"Ronald D.","family":"Bass","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine, Washington, DC, and University of Texas Southwestern  Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9469-0919","authenticated-orcid":false,"given":"Duncan F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Northwestern Memorial Hospital  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia D.","family":"Steen","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.07.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00668-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170953"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101248"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12884"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23861"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218546"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.220100"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11073"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37795"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218272"},{"issue":"4","key":"e_1_2_6_19_1","first-page":"330","article-title":"Manifestations of systemic lupus erythematosus","volume":"6","author":"Cojocaru M","year":"2011","journal-title":"Maedica (Bucur)"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2020-000394"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.25235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:17:50Z","timestamp":1759425470000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.25235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/acr.25235"],"URL":"https:\/\/doi.org\/10.1002\/acr.25235","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"2023-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}