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We examined the effects of a 12\u2010week resilience\u2010building energy management program (called RENEW) for fatigue and other patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants, who had physician\u2010diagnosed SSc, moderate to severe fatigue, and were \u226518\u2009years old, were randomly assigned to RENEW or waitlist control in a 2:1 ratio. The RENEW intervention included an educational website\/application plus nine virtual peer\u2010led health coaching sessions. The primary outcome was change in the Functional Assessment of Chronic Illness Therapy\u2010Fatigue scale. Secondary outcomes were change in Patient Reported Outcomes Measurement Information System measures of pain interference and depressive symptoms and Connor\u2010Davidson Resilience Scale. Outcomes were assessed at baseline, 6\u2009weeks, and 12\u2009weeks. Multiple imputation was conducted; linear mixed models were used to assess group differences. A three\u2010way interaction with group, time, and SSc duration was examined in each model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 173 participants (mean \u00b1 SD age 54.5 \u00b1\u200911.7\u2009years; 93% female, 85% White), 47% had diffuse cutaneous SSc; 57% were \u22645\u2009years from diagnosis. At 12\u2009weeks, compared to controls, RENEW participants had a clinically meaningful fatigue improvement (\u03b2 = \u22124.7; 95% confidence interval \u22126.7 to \u22122.7; <jats:italic>P<\/jats:italic> &lt;\u20090.001) and improvement in all secondary outcomes. Among RENEW participants, individuals with shorter disease duration had greater improvements in fatigue at 12\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An mHealth supported self\u2010management intervention improved fatigue and other outcomes, particularly in newly diagnosed patients. This program may be broadly scalable for SSc symptom management.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/acr25253-toc-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25253","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:22:42Z","timestamp":1697512962000},"page":"318-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of a <scp>Resilience\u2010Building<\/scp> Energy Management Program on Fatigue and Other Symptoms in Systemic Sclerosis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-0012","authenticated-orcid":false,"given":"Susan L.","family":"Murphy","sequence":"first","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen T.","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Alore","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri","family":"Hicks","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pape","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-484X","authenticated-orcid":false,"given":"Afton L.","family":"Hassett","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-3898","authenticated-orcid":false,"given":"Anna L.","family":"Kratz","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Whibley","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-3879","authenticated-orcid":false,"given":"Alexandra E.","family":"Harper","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann 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