{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:49:17Z","timestamp":1769129357646,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the relationships of work productivity and activity impairment with key patient\u2010reported outcomes (PROs) assessing pain, disease activity, and health\u2010related quality of life (HRQoL) in patients with ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc analysis pooled available data from baseline to end of the double\u2010blind phase of phase 2 and 3 placebo\u2010controlled tofacitinib trials in patients with active AS. A repeated\u2010measures longitudinal model assessed the relationships (linear or nonlinear) between Work Productivity and Activity Impairment questionnaire in Spondyloarthritis (WPAI:SpA) domains (absenteeism, activity impairment, presenteeism, and productivity loss) as outcomes and key PROs (total back pain, nocturnal spinal pain, Patient Global Assessment of Disease Activity, AS Quality of Life, EuroQol 5\u2010Dimension 3\u2010Level [EQ\u20105D\u20103L], and EQ\u20105D Visual Analog Scale [EQ\u20105D\u2010VAS]) as predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 330 to 475 patients were available, depending on the analysis. Relationships between WPAI:SpA domains and PROs were approximately linear. The worst PRO scores were associated with a decline in patients\u2019 work capacity (measured by activity impairment, presenteeism, and productivity loss [&gt;65%]); the best scores were associated with improvements in WPAI:SpA domains (8%\u201323%). Incremental PRO improvements were associated with improvement of activity impairment, presenteeism, and productivity loss. Relationships between absenteeism and PROs were the weakest, owing to absenteeism being low in the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evidence of linear relationships between work productivity and activity impairment with patient\u2010reported pain, disease activity, and HRQoL was observed. Interventions to control pain and disease activity and improve HRQoL are therefore likely to improve work productivity and reduce activity impairment in patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25267","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T05:58:19Z","timestamp":1698818299000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relationships of Work Productivity and Activity Impairment With <scp>Patient\u2010Reported<\/scp> Outcomes in Ankylosing Spondylitis: Results From Two Trials"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-5619","authenticated-orcid":false,"given":"Marina","family":"Magrey","sequence":"first","affiliation":[{"name":"Case Western Reserve University and Division of Rheumatology, University Hospitals Cleveland Medical Center  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Chung Shan Medical University Hospital and Graduate Institute of Integrated Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Yndestad","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Bushmakin","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Groton Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Cappelleri","sequence":"additional","affiliation":[{"name":"Pfizer Inc  Groton Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseyi","family":"Dina","sequence":"additional","affiliation":[{"name":"Pfizer Inc  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-1246","authenticated-orcid":false,"given":"Atul","family":"Deodhar","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; 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