{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:03:34Z","timestamp":1784822614906,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2503300"],"award-info":[{"award-number":["2022YFC2503300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2022YFE0107600"],"award-info":[{"award-number":["2022YFE0107600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["AR\u2010060772"],"award-info":[{"award-number":["AR\u2010060772"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is an unmet need for simpler urate\u2010lowering therapy (ULT) regimens that achieve the serum urate target and improve the overall quality of gout care. We report a comparative effectiveness trial of febuxostat monotherapy versus benzbromarone add\u2010on to low\u2010dose febuxostat in gout specifically with combined renal urate underexcretion and overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective randomized trial was conducted on patients with combined\u2010type hyperuricemia and estimated glomerular filtration rate &gt;60 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> 1:1 randomly assigned to febuxostat and benzbromarone combination therapy (initially febuxostat at 20 mg\/day, with benzbromarone at 25 mg\/day added onto 20 mg\/day of febuxostat if not at target) or febuxostat monotherapy (initially 20 mg\/day, escalating to 40 mg\/day if not at target). The primary end point at 12\u2009weeks was the proportion achieving a serum urate (SU) level &lt;360 \u03bcmol\/L. Other outcomes included altered liver and kidney function, new\u2010onset urolithiasis, and gout flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 250 participants randomized; 219 completed 12\u2010week treatment. More patients in the febuxostat and benzbromarone combination group achieved the SU target compared to patients in the febuxostat monotherapy group (75.5% vs 47.7%; odds ratio 3.37 [95% confidence interval 1.90\u20135.98]). Safety profiles were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simply adding on low\u2010dose benzbromarone (25 mg\/day) to low\u2010dose (20 mg\/day) febuxostat showed superior urate lowering compared to febuxostat monotherapy in gout with a combined\u2010type hyperuricemia. For selected patients, expedited achievement of the SU target in more than 75% of patients using one titration step and low xanthine oxidase inhibitor and uricosuric doses is a potential alternative to standard ULT regimens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25283","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:04:15Z","timestamp":1703207055000},"page":"703-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Superiority of <scp>Low\u2010Dose<\/scp> Benzbromarone <scp>Add\u2010On<\/scp> to <scp>Low\u2010Dose<\/scp> Febuxostat Compared With Febuxostat Monotherapy in Gout With <scp>Combined\u2010Type<\/scp> Hyperuricemia"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-0130","authenticated-orcid":false,"given":"Xiaomei","family":"Xue","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Qingdao University  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