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We investigated the association of weight change with incidence and progression of radiographic hand OA and the development and resolution of hand pain. Using multivariable logistic regression, we investigated the association of weight change from baseline to the 4\u2010year follow\u2010up with the incidence and progression of radiographic hand OA at the 4\u2010year follow\u2010up. Additionally, multivariable repeated\u2010measure mixed\u2010effects logistic regression analyzed the association of weight change with the development and resolution of hand pain across 2\u2010year, 4\u2010year, 6\u2010year, and 8\u2010year follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant associations were observed between weight change and the investigated outcomes. Specifically, for each 5% weight loss, the odds ratios for the incidence and progression of radiographic hand OA were 0.90 (95% confidence interval [95% CI] 0.67\u20131.23) and 0.92 (95% CI 0.84\u20131.00), respectively. Similarly, for each 5% weight loss, the odds ratios for the development and resolution of hand pain at the 8\u2010year follow\u2010up were 1.00 (95% CI 0.92\u20131.09) and 1.07 (95% CI 0.91\u20131.25), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study found no evidence of an association between weight change and the odds of incidence or progression of radiographic hand OA over 4\u2009years, nor the development or resolution of hand pain over 8\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25284","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:58:21Z","timestamp":1703206701000},"page":"652-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of Weight Loss and Weight Gain With Structural Defects and Pain in Hand Osteoarthritis: Data From the Osteoarthritis 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